Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | BRD2 | P25440 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.40 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.34 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4872480 | 0.87 | GPR119 (0.39) | BRD4BRD2CREBBPGPR119PORCN | |
| SCHEMBL4881407 | 0.79 | NPC1 (0.38) | GPR119PORCNNPC1RAB9AKDM4E | |
| SCHEMBL20838307 | 0.77 | MEN1 (0.51) | FFAR1NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL644797 | 0.77 | FFAR1 (0.49) | FFAR1NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL4881273 | 0.77 | GLRA3 (0.42) | BRD4BRD2CREBBPFFAR1NPC1 | |
| SCHEMBL10415202 | 0.73 | MEN1 (0.46) | FFAR1NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL4879486 | 0.71 | GPBAR1 (0.51) | FFAR1NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL475579 | 0.71 | KDM4E (0.43) | GPR119NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL4880394 | 0.70 | FFAR1 (0.44) | FFAR1NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL2526307 | 0.70 | FFAR1 (0.44) | BRD4BRD2CREBBPFFAR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080132477-A1 | Macrocyclic Compounds Useful as Bace Inhibitors | NOVARTIS AG (CH) | 2008-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080132477-A1 | Macrocyclic Compounds Useful as Bace Inhibitors | BACE1, BACE2, APP | BRD4 299/4885BRD2 560/4885CREBBP 1784/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.