Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.55 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.55 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | GPR68 | Q15743 | 1/20 | 0.40 |
| ▸ | MPL | P40238 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | SNCA | P37840 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | KLK7 | P49862 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4868905 | 0.82 | MPL (0.58) | ADORA2AADORA1ADORA3ADORA2BMPL | |
| SCHEMBL4868755 | 0.81 | ADORA3 (0.53) | ADORA2AADORA1ADORA3ADORA2BCYP19A1 | |
| Hydrochloric Acid SCHEMBL4877713 | 0.81 | MPL (0.57) | ADORA2AADORA1ADORA3ADORA2BMPL | |
| SCHEMBL16238754 | 0.79 | ADORA3 (0.66) | ADORA2AADORA1ADORA3ADORA2BCYP19A1 | |
| SCHEMBL9852272 | 0.76 | ADORA3 (0.66) | ADORA2AADORA1ADORA3ADORA2BCYP19A1 | |
| SCHEMBL9852130 | 0.75 | NPC1 (0.58) | ADORA2AADORA1ADORA3ADORA2BCYP19A1 | |
| SCHEMBL27095781 | 0.74 | NOTUM (0.47) | ADORA2AADORA1GPR68MAPTDPP4 | |
| SCHEMBL32675514 | 0.74 | NOTUM (0.47) | ADORA2AADORA1GPR68MAPTDPP4 | |
| SCHEMBL11327119 | 0.74 | ADORA2A (0.62) | ADORA2AADORA1ADORA3ADORA2BCYP19A1 | |
| SCHEMBL20267788 | 0.73 | ADORA3 (0.47) | ADORA2AADORA1ADORA3ADORA2BCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080076771-A1 | Thrombopoietin Receptor Agonists | REITER LAWRENCE A | 2008-03-27 | — | — | US | disclosed |
| EP-1794156-A2 | TROMBOPOIETIN RECEPTOR AGONISTS | Pfizer Products Incorporated (US) | 2007-06-13 | — | — | EP | disclosed |
| WO-2006033005-A2 | THROMBOPOIETIN RECEPTOR AGONISTS | PFIZER PRODUCTS INC. (US) | 2006-03-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076771-A1 | Thrombopoietin Receptor Agonists | MPL, THPO, TBXA2R | ADORA2A 298/4885ADORA1 366/4885ADORA3 393/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.