Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.34 |
| ▸ | TUBB | P07437 | 1/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2166315 | 0.79 | ALDH1A1 (0.49) | CYP2C19ALDH1A1KMT2AMEN1KEAP1 | |
| SCHEMBL4869046 | 0.78 | ALDH1A1 (0.40) | CYP2C19ALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL4878194 | 0.77 | ALDH1A1 (0.47) | CYP2C19ALDH1A1LMNACYP2D6KEAP1 | |
| SCHEMBL4876866 | 0.77 | ALDH1A1 (0.46) | CYP2C19ALDH1A1LMNACYP2D6KEAP1 | |
| SCHEMBL3128908 | 0.75 | CYP2C19 (0.47) | CYP2C19ALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL4875369 | 0.72 | HRH4 (0.48) | CYP2C19ALDH1A1LMNACYP2D6SMN1; SMN2 | |
| SCHEMBL4877590 | 0.72 | CYP2C19 (0.51) | CYP2C19ALDH1A1KMT2AMEN1CYP2D6 | |
| SCHEMBL4875265 | 0.72 | CYP2C19 (0.43) | CYP2C19ALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL606302 | 0.71 | HRH4 (0.59) | CCNE2CDK4CCND1CCNE1CDK2 | |
| SCHEMBL3131985 | 0.71 | CYP2C19 (0.47) | CYP2C19ALDH1A1LMNACYP2D6KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8735411-B2 | Macrocyclic benzofused pyrimidine derivatives | ABBVIE INC. (US) | 2014-05-27 | — | — | US | disclosed |
| US-20080188452-A1 | Macrocyclic Benzofused Pyrimidine Derivatives | ABBVIE INC. | 2008-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080188452-A1 | Macrocyclic Benzofused Pyrimidine Derivatives | DPYD, TYMS, UMPS | CYP2C19 685/4885ALDH1A1 411/4885KMT2A 2423/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.