SCHEMBL4877112

SCHEMBL4877112

CC(C)(C)[Si](C)(C)OCCNc1ccc(NC(=O)c2[nH]cnc2C(=O)O)cc1

nearest known ligand 0.48

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.48
TDP1 Q9NUW8 2/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
MAPT P10636 9/20 0.48
KMT2A Q03164 3/20 0.45
POLB P06746 2/20 0.44
XBP1 P17861 1/20 0.44
HSD17B10 Q99714 1/20 0.44
MAPK1 P28482 2/20 0.43
ATM Q13315 2/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
KDM4E B2RXH2 2/20 0.43
ALDH1A1 P00352 1/20 0.43
MEN1 O00255 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4881662 0.91 TDP1 (0.47) GAATDP1L3MBTL1MAPTKMT2A
SCHEMBL14066581 0.89 MAPT (0.59) GAATDP1L3MBTL1MAPTKMT2A
SCHEMBL4881576 0.88 GAA (0.47) GAATDP1L3MBTL1MAPTKMT2A
SCHEMBL5240553 0.87 GAA (0.40) GAATDP1L3MBTL1MAPTKMT2A
SCHEMBL14066580 0.83 MAPT (0.53) GAATDP1L3MBTL1MAPTKMT2A
SCHEMBL5239859 0.82 GAA (0.40) GAATDP1L3MBTL1MAPTKMT2A
SCHEMBL5586084 0.76 POLB (0.42) POLBHSD17B10MAPK1SMN1; SMN2ALDH1A1
SCHEMBL4882033 0.73 MLYCD (0.42) GAAL3MBTL1MAPTKMT2APOLB
SCHEMBL4881556 0.73 MAPT (0.42) GAAL3MBTL1MAPTSMN1; SMN2KDM4E
SCHEMBL4882264 0.73 MAPT (0.39) GAATDP1L3MBTL1MAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080214533-A1 Cyclic Iminocarbamates And Their Use BAYER HEALTHCARE AG (DE) 2008-09-04 US disclosed
US-20080214533-A1 Cyclic Iminocarbamates And Their Use BAYER HEALTHCARE AG (DE) 2008-09-04 US disclosed
EP-1819701-A1 CYCLIC IMINOCARBAMATES AND USE THEREOF Bayer HealthCare AG (DE) 2007-08-22 EP disclosed
WO-2006058630-A1 CYCLIC IMINOCARBAMATES AND USE THEREOF BAYER HEALTHCARE AG (DE) 2006-06-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080214533-A1 Cyclic Iminocarbamates And Their Use F2, UQCRB, F12 GAA 3652/4885TDP1 3261/4885L3MBTL1 2946/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.