Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.40 |
| ▸ | KDM4A | O75164 | 12/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 12/20 | 0.39 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.39 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.39 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28165411 | 0.82 | TSHR (0.46) | TSHRMEN1KMT2A | |
| SCHEMBL10699569 | 0.80 | LMNA (0.41) | TSHRKMT2A | |
| SCHEMBL11599334 | 0.79 | CNR2 (0.42) | TSHR | |
| SCHEMBL991447 | 0.77 | CNR2 (0.49) | DNM1TSHR | |
| SCHEMBL28428571 | 0.76 | TSHR (0.36) | TSHR | |
| SCHEMBL713902 | 0.76 | TSHR (0.64) | PAOXKDM4AKDM4CDNM1KDM5A | |
| SCHEMBL28360017 | 0.76 | DGKA (0.52) | TSHRMEN1KMT2A | |
| SCHEMBL27700699 | 0.76 | DGKA (0.52) | TSHRMEN1KMT2A | |
| SCHEMBL29199661 | 0.76 | DGKA (0.52) | TSHRMEN1KMT2A | |
| SCHEMBL29169676 | 0.76 | DGKA (0.52) | TSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004078116-A9 | P38 INHIBITORS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC (US) | 2008-09-12 | — | — | WO | disclosed |