Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 4/20 | 0.63 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.45 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4871692 | 0.89 | CYP19A1 (0.50) | CYP19A1NPC1POLBMEN1KMT2A | |
| SCHEMBL7514925 | 0.84 | CYP19A1 (0.82) | CYP19A1NPC1POLBMEN1KMT2A | |
| SCHEMBL15058859 | 0.84 | CYP19A1 (0.81) | CYP19A1NPC1MEN1KMT2ACDK5 | |
| SCHEMBL14904717 | 0.82 | CYP19A1 (0.69) | CYP19A1NPC1POLBMEN1KMT2A | |
| SCHEMBL7518475 | 0.79 | CYP19A1 (0.65) | CYP19A1NPC1POLBMEN1KMT2A | |
| SCHEMBL13191447 | 0.79 | CYP19A1 (0.65) | CYP19A1NPC1POLBMEN1KMT2A | |
| SCHEMBL4866651 | 0.79 | CYP19A1 (0.65) | CYP19A1NPC1POLBMEN1KMT2A | |
| SCHEMBL10172987 | 0.79 | CYP19A1 (0.65) | CYP19A1NPC1POLBMEN1KMT2A | |
| SCHEMBL15073406 | 0.79 | CYP19A1 (0.72) | CYP19A1NPC1MEN1KMT2ACDK5 | |
| SCHEMBL11556289 | 0.78 | CYP19A1 (1.00) | CYP19A1NPC1MEN1KMT2ACDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7375118-B2 | Phenyl-indole compounds for modulating IgE and Inhibiting cellular proliferation | AVANIR PHARMACEUTICALS (US) | 2008-05-20 | — | — | US | disclosed |
| EP-1537079-A4 | PHENYL-INDOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION | AVANIR PHARMACEUTICALS (US) | 2007-05-16 | — | — | EP | disclosed |
| CN-1694868-A | Phenyl-indole compounds for modulating IgE and inhibiting cell proliferation | AVANIR PHARMACEUTICALS (US) | 2005-11-09 | — | — | CN | disclosed |
| EP-1537079-A2 | PHENYL-INDOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION | AVANIR PHARMACEUTICALS (US) | 2005-06-08 | — | — | EP | disclosed |
| US-20040180946-A1 | Phenyl-indole compounds for modulating IgE and inhibiting cellular proliferation | AVANIR PHARMACEUTICALS | 2004-09-16 | — | — | US | disclosed |
| WO-2004024896-A2 | PHENYL-INDOLE COMPOUNDS | AVANIR PHARMACEUTICALS (US) | 2004-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040180946-A1 | Phenyl-indole compounds for modulating IgE and inhibiting cellular proliferation | IDO1, IDO2, CMA1 | CYP19A1 1281/4885NPC1 3700/4885POLB 3894/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.