Sugi Predict

Sugi Predict / Compounds / SCHEMBL487823

SCHEMBL487823

SCHEMBL487823

Nc1ncc(-c2ccc(NS(=O)(=O)CCNCC3CC3)cc2)nc1OCc1c(F)ccc(F)c1Cl

nearest known ligand 0.37

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ CSF1R P07333 2/20 0.37
▸ MET P08581 4/20 0.35
▸ SGK1 O00141 8/20 0.35
▸ PIK3CD O00329 3/20 0.34
▸ PIK3CA P42336 3/20 0.34
▸ PIK3CB P42338 3/20 0.34
▸ PIK3CG P48736 3/20 0.34
▸ CYP3A4 P08684 1/20 0.34
▸ SGK3 Q96BR1 1/20 0.34
▸ SGK2 Q9HBY8 1/20 0.34
▸ CHEK2 O96017 2/20 0.33
▸ MAPK1 P28482 1/20 0.33
▸ ATR Q13535 1/20 0.33
▸ MAP4K3 Q8IVH8 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30452931 1.00 CSF1R (0.37) CSF1RMETSGK1PIK3CDPIK3CA
SCHEMBL488496 0.91 TYRO3 (0.42) CSF1RPIK3CDPIK3CAPIK3CBPIK3CG
SCHEMBL30453889 0.91 TYRO3 (0.42) CSF1RPIK3CDPIK3CAPIK3CBPIK3CG
SCHEMBL30453160 0.89 CSF1R (0.37) CSF1RMETSGK1PIK3CDPIK3CA
SCHEMBL487878 0.89 CSF1R (0.37) CSF1RMETSGK1PIK3CDPIK3CA
SCHEMBL30453744 0.85 MET (0.50) METMAP4K3
SCHEMBL487916 0.85 MET (0.50) METMAP4K3
SCHEMBL488492 0.85 MAP4K3 (0.46) METSGK1PIK3CDPIK3CAPIK3CB
SCHEMBL30453976 0.85 MAP4K3 (0.46) METSGK1PIK3CDPIK3CAPIK3CB
SCHEMBL488100 0.84 CSF1R (0.41) CSF1RMETSGK1PIK3CDPIK3CA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4695588-B2 — — 2011-06-08 — — JP claimed
US-8106197-B2 Aminoheteroaryl compounds as protein kinase inhibitors PFIZER INC. (US) 2012-01-31 — — US disclosed
US-8106197-B2 Aminoheteroaryl compounds as protein kinase inhibitors PFIZER INC. (US) 2012-01-31 — — US disclosed
US-8106197-B2 Aminoheteroaryl compounds as protein kinase inhibitors PFIZER INC. (US) 2012-01-31 — — US disclosed
US-7230098-B2 2-amino- pyridines and pyrazines additionally substituted witn one or more carbocyclic or heterocyclic groups, e.g., 4-[6-amino-5-(2,6-dichloro-benzyloxy)-pyridin-3-yl]-phenol, for treating many kinds of cancer SUGEN, INC. (US) 2007-06-12 — — US disclosed
US-7230098-B2 2-amino- pyridines and pyrazines additionally substituted witn one or more carbocyclic or heterocyclic groups, e.g., 4-[6-amino-5-(2,6-dichloro-benzyloxy)-pyridin-3-yl]-phenol, for treating many kinds of cancer SUGEN, INC. (US) 2007-06-12 — — US disclosed
US-20070072874-A1 Aminoheteroaryl compounds as protein kinase inhibitors SUGEN, INC. 2007-03-29 — — US disclosed
US-20070072874-A1 Aminoheteroaryl compounds as protein kinase inhibitors SUGEN, INC. 2007-03-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070072874-A1 Aminoheteroaryl compounds as protein kinase inhibitors MET, MAP4K1, MAP4K2 CSF1R 757/4885MET 1/4885SGK1 235/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.