Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 18/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 18/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.62 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4881228 | 0.84 | CYP3A4 (0.61) | CYP3A4CYP2C9CYP2D6CYP1A2MCHR1 | |
| SCHEMBL4890938 | 0.84 | CYP3A4 (0.61) | CYP3A4CYP2C9CYP2D6CYP1A2MCHR1 | |
| SCHEMBL14021366 | 0.79 | CYP3A4 (1.00) | CYP3A4CYP2C9CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL14021363 | 0.77 | CYP3A4 (1.00) | CYP3A4CYP2C9CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL4881820 | 0.77 | CYP3A4 (0.85) | CYP3A4CYP2C9CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL4882282 | 0.77 | CYP3A4 (1.00) | CYP3A4CYP2C9CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL4878917 | 0.77 | CYP3A4 (0.77) | CYP3A4CYP2C9CYP2D6CYP1A2MCHR1 | |
| Hydrochloric Acid SCHEMBL4891112 | 0.77 | CYP3A4 (0.98) | CYP3A4CYP2C9CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL14021360 | 0.76 | CYP3A4 (0.81) | CYP3A4CYP2C9CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL14021357 | 0.76 | CYP3A4 (0.81) | CYP3A4CYP2C9CYP2D6CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100311740-A1 | IMIDAZOPYRIDINE DERIVATIVES AS ACID PUMP ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2010-12-09 | — | — | US | disclosed |
| US-20100311740-A1 | IMIDAZOPYRIDINE DERIVATIVES AS ACID PUMP ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2010-12-09 | — | — | US | disclosed |
| US-20080255358-A1 | Derivatives of Imidazo [1,2-A] Pyridine Useful as Medicaments For Treating Gastrointestinal Diseases | GLAXO GROUP LIMITED (GB) | 2008-10-16 | — | — | US | disclosed |
| US-20080255358-A1 | Derivatives of Imidazo [1,2-A] Pyridine Useful as Medicaments For Treating Gastrointestinal Diseases | GLAXO GROUP LIMITED (GB) | 2008-10-16 | — | — | US | disclosed |
| WO-2007003386-A9 | IMIDAZOPYRIDINE DERIVATIVES AS ACID PUMP ANTAGONISTS | GLAXO GROUP LTD (GB) | 2008-09-18 | — | — | WO | disclosed |
| EP-1861095-A1 | DERIVATIVES OF IMIDAZO(1,2-A)PYRIDINE USEFUL AS MEDICAMENTS FOR TREATING GASTROINTESTINAL DISEASES | GLAXO GROUP LIMITED (GB) | 2007-12-05 | — | — | EP | disclosed |
| WO-2007003386-A1 | IMIDAZOPYRIDINE DERIVATIVES AS ACID PUMP ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2007-01-11 | — | — | WO | disclosed |
| WO-2006100119-A1 | DERIVATIVES OF IMIDAZO (1,2-A) PYRIDINE USEFUL AS MEDICAMENTS FOR TREATING GASTROINTESTINAL DISEASES | GLAXO GROUP LIMITED (GB) | 2006-09-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255358-A1 | Derivatives of Imidazo [1,2-A] Pyridine Useful as Medicaments For Treating Gastrointestinal Diseases | ALPI, PYGL, PPIP5K2 | CYP3A4 215/4885CYP2C9 1357/4885CYP2D6 289/4885 |
| US-20100311740-A1 | IMIDAZOPYRIDINE DERIVATIVES AS ACID PUMP ANTAGONISTS | HRH2, GIPR, MLNR | CYP3A4 151/4885CYP2C9 585/4885CYP2D6 139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.