Phenanthroline

Phenanthroline

SCHEMBL4881417

CC(=O)O.c1cnc2c(c1)ccc1cccnc12

nearest known ligand 0.70

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Phenanthroline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 5/20 0.70
CCR1 P32246 3/20 0.70
CCR5 P51681 3/20 0.70
CCR8 P51685 3/20 0.70
KDM4E B2RXH2 3/20 0.70
TDP1 Q9NUW8 3/20 0.70
MAPT P10636 2/20 0.70
HTT P42858 2/20 0.70
SMN1; SMN2 Q16637 2/20 0.70
MMP2 P08253 2/20 0.70
TSHR P16473 2/20 0.70
GMNN O75496 1/20 0.70
TP53 P04637 1/20 0.70
HSP90AA1 P07900 1/20 0.70
CYP3A4 P08684 1/20 0.70
CYP2D6 P10635 1/20 0.70
MMP9 P14780 1/20 0.70
ALOX15 P16050 1/20 0.70
NFKB1 P19838 1/20 0.70
MMP8 P22894 1/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phenanthroline SCHEMBL22401704 1.00 LMNA (0.70) LMNACCR1CCR5CCR8KDM4E
Phenanthroline SCHEMBL29278213 0.98 LMNA (0.67) LMNACCR1CCR5CCR8KDM4E
Phenanthroline SCHEMBL29521774 0.98 LMNA (0.67) LMNACCR1CCR5CCR8KDM4E
Phenanthroline SCHEMBL3408768 0.98 LMNA (0.67) LMNACCR1CCR5CCR8KDM4E
Phenanthroline SCHEMBL28097109 0.93 LMNA (0.73) LMNACCR1CCR5CCR8KDM4E
Phenanthroline SCHEMBL28776402 0.88 LMNA (0.59) LMNACCR1CCR5CCR8KDM4E
Phenanthroline SCHEMBL2532986 0.88 KDM4E (0.64) LMNACCR1CCR5CCR8KDM4E
Phenanthroline SCHEMBL29278214 0.88 KDM4E (0.64) LMNACCR1CCR5CCR8KDM4E
Phenanthroline SCHEMBL29188565 0.88 KDM4E (0.64) LMNACCR1CCR5CCR8KDM4E
Phenanthroline SCHEMBL16192743 0.88 KDM4E (0.64) LMNACCR1CCR5CCR8KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9024077-B2 Fluorine-containing vinyl ether compound and method for producing the same UNIMATEC CO., LTD. (JP) 2015-05-05 US claimed
EP-2617700-B1 NOVEL FLUORINATED VINYL ETHER COMPOUND AND MANUFACTURING METHOD THEREFOR UNIMATEC CO LTD (JP) 2014-10-29 EP claimed
EP-2617700-A1 NOVEL FLUORINATED VINYL ETHER COMPOUND AND MANUFACTURING METHOD THEREFOR Unimatec Co., Ltd. (JP) 2013-07-24 EP claimed
US-20130178659-A1 NOVEL FLUORINE-CONTAINING VINYL ETHER COMPOUND AND METHOD FOR PRODUCING THE SAME UNIMATEC CO., LTD. (JP) 2013-07-11 US claimed
US-20080090977-A1 Fluorine-Containing Vinyl Ether Compound And Process For Producing The Same UNIMATEC CO., LTD. (JP) 2008-04-17 US claimed
EP-1760063-A1 FLUORINE-CONTAINING VINYL ETHER COMPOUND AND PROCESS FOR PRODUCING THE SAME Unimatec Co., Ltd. (JP) 2007-03-07 EP claimed
CN-104395316-B Benzimidazo [1,2-A ] benzimidazole derivatives for electronic applications UDC 爱尔兰有限责任公司 2018-01-19 CN disclosed
CN-104588003-B A kind of heterogeneous metal catalyst and its application in isobutanol is prepared by methanol and ethanol water 中国科学院青岛生物能源与过程研究所 2017-11-07 CN disclosed
CN-106986870-A Organic electric field color changing device and o-diazaphenanthrene based compound used for the same 机光科技股份有限公司 2017-07-28 CN disclosed
US-9024077-B2 Fluorine-containing vinyl ether compound and method for producing the same UNIMATEC CO., LTD. (JP) 2015-05-05 US disclosed
EP-2617700-B1 NOVEL FLUORINATED VINYL ETHER COMPOUND AND MANUFACTURING METHOD THEREFOR UNIMATEC CO LTD (JP) 2014-10-29 EP disclosed
EP-2617700-A1 NOVEL FLUORINATED VINYL ETHER COMPOUND AND MANUFACTURING METHOD THEREFOR Unimatec Co., Ltd. (JP) 2013-07-24 EP disclosed
US-20130178659-A1 NOVEL FLUORINE-CONTAINING VINYL ETHER COMPOUND AND METHOD FOR PRODUCING THE SAME UNIMATEC CO., LTD. (JP) 2013-07-11 US disclosed
US-20080090977-A1 Fluorine-Containing Vinyl Ether Compound And Process For Producing The Same UNIMATEC CO., LTD. (JP) 2008-04-17 US disclosed
EP-1760063-A1 FLUORINE-CONTAINING VINYL ETHER COMPOUND AND PROCESS FOR PRODUCING THE SAME Unimatec Co., Ltd. (JP) 2007-03-07 EP disclosed