Sugi Predict

Sugi Predict / Compounds / SCHEMBL488165

SCHEMBL488165

SCHEMBL488165

Nc1ncc(-c2ccc(NS(=O)(=O)CCN3CC[C@@H](O)C3)cc2)nc1OCc1c(F)ccc(F)c1Cl

nearest known ligand 0.40

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ CSF1R P07333 2/20 0.40
▸ MET P08581 4/20 0.38
▸ PDCD1 Q15116 4/20 0.34
▸ CD274 Q9NZQ7 4/20 0.34
▸ JAK2 O60674 1/20 0.34
▸ JAK3 P52333 1/20 0.34
▸ ATR Q13535 1/20 0.34
▸ MAP4K4 O95819 3/20 0.34
▸ SGK1 O00141 1/20 0.34
▸ AXL P30530 1/20 0.33
▸ MERTK Q12866 1/20 0.33
▸ KDR P35968 1/20 0.33
▸ AURKB Q96GD4 1/20 0.33
▸ PLA2G4A P47712 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30452621 1.00 CSF1R (0.40) CSF1RMETPDCD1CD274JAK2
SCHEMBL30452779 0.95 CSF1R (0.41) CSF1RMETJAK2JAK3MAP4K4
SCHEMBL488100 0.95 CSF1R (0.41) CSF1RMETJAK2JAK3MAP4K4
SCHEMBL30453003 0.92 TYRO3 (0.39) CSF1RMETPDCD1CD274ATR
SCHEMBL488417 0.92 TYRO3 (0.39) CSF1RMETPDCD1CD274ATR
SCHEMBL30453605 0.89 MAP4K4 (0.43) CSF1RMETATRMAP4K4SGK1
SCHEMBL487892 0.89 MAP4K4 (0.43) CSF1RMETATRMAP4K4SGK1
SCHEMBL487716 0.88 MAP4K4 (0.44) CSF1RMETATRMAP4K4SGK1
SCHEMBL30453212 0.88 MAP4K4 (0.44) CSF1RMETATRMAP4K4SGK1
SCHEMBL488554 0.88 TYRO3 (0.40) CSF1RMETATRMAP4K4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4695588-B2 — — 2011-06-08 — — JP claimed
US-8106197-B2 Aminoheteroaryl compounds as protein kinase inhibitors PFIZER INC. (US) 2012-01-31 — — US disclosed
US-8106197-B2 Aminoheteroaryl compounds as protein kinase inhibitors PFIZER INC. (US) 2012-01-31 — — US disclosed
US-8106197-B2 Aminoheteroaryl compounds as protein kinase inhibitors PFIZER INC. (US) 2012-01-31 — — US disclosed
US-7230098-B2 2-amino- pyridines and pyrazines additionally substituted witn one or more carbocyclic or heterocyclic groups, e.g., 4-[6-amino-5-(2,6-dichloro-benzyloxy)-pyridin-3-yl]-phenol, for treating many kinds of cancer SUGEN, INC. (US) 2007-06-12 — — US disclosed
US-7230098-B2 2-amino- pyridines and pyrazines additionally substituted witn one or more carbocyclic or heterocyclic groups, e.g., 4-[6-amino-5-(2,6-dichloro-benzyloxy)-pyridin-3-yl]-phenol, for treating many kinds of cancer SUGEN, INC. (US) 2007-06-12 — — US disclosed
US-20070072874-A1 Aminoheteroaryl compounds as protein kinase inhibitors SUGEN, INC. 2007-03-29 — — US disclosed
US-20070072874-A1 Aminoheteroaryl compounds as protein kinase inhibitors SUGEN, INC. 2007-03-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070072874-A1 Aminoheteroaryl compounds as protein kinase inhibitors MET, MAP4K1, MAP4K2 CSF1R 757/4885MET 1/4885PDCD1 2274/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.