Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 12/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 11/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 9/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 10/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.51 |
| ▸ | USP2 | O75604 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16815363 | 0.83 | CYP2A6 (0.56) | CYP2A6CYP1A2CYP3A4CYP2D6ALDH1A1 | |
| SCHEMBL27135558 | 0.82 | MAPT (0.42) | CYP1A2CYP3A4CYP2D6ALDH1A1HSD17B10 | |
| SCHEMBL19797757 | 0.79 | TRPV3 (0.41) | CYP1A2CYP3A4CYP2D6ALDH1A1MAPK1 | |
| SCHEMBL10817963 | 0.77 | CYP2A6 (0.62) | CYP2A6CYP1A2CYP3A4CYP2D6ALDH1A1 | |
| SCHEMBL8152928 | 0.76 | CYP2A6 (0.51) | CYP2A6CYP1A2CYP3A4CYP2D6ALDH1A1 | |
| SCHEMBL23370157 | 0.76 | CYP1A2 (0.39) | CYP1A2ALDH1A1TDP1CLK4KDM4E | |
| SCHEMBL10272457 | 0.75 | CYP2A6 (0.52) | CYP2A6CYP1A2CYP3A4CYP2D6ALDH1A1 | |
| SCHEMBL2759492 | 0.75 | CYP2A6 (0.62) | CYP2A6CYP1A2CYP3A4ALDH1A1LMNA | |
| SCHEMBL28021728 | 0.74 | PDE4B (0.53) | CYP1A2CYP3A4ALDH1A1HSD17B10LMNA | |
| SCHEMBL4631413 | 0.74 | CYP2A6 (0.62) | CYP2A6CYP1A2CYP3A4CYP2D6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009050228-A2 | CSF-1R INHIBITORS FOR TREATMENT OF CANCER AND BONE DISEASES | NOVARTIS AG (CH) | 2009-04-23 | — | — | WO | disclosed |
| US-20080146570-A1 | Chemical Compounds | ASTRAZENECA AB (SE) | 2008-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146570-A1 | Chemical Compounds | BRAF, RAF1, NRAS | CYP2A6 1192/4885CYP1A2 1194/4885CYP3A4 2085/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.