Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 12/20 | 0.52 |
| ▸ | PPARA | Q07869 | 4/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 3/20 | 0.41 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4467143 | 0.87 | FBP1 (0.53) | FBP1PPARATSHRABCB11CYP1A2 | |
| SCHEMBL4423002 | 0.81 | PPARA (0.59) | FBP1PPARATSHRABCB11CYP1A2 | |
| SCHEMBL4111678 | 0.80 | FBP1 (0.58) | FBP1PPARATSHRABCB11CYP1A2 | |
| SCHEMBL12670823 | 0.79 | FBP1 (0.56) | FBP1PPARATSHRABCB11CYP1A2 | |
| SCHEMBL14092161 | 0.78 | FBP1 (0.55) | FBP1PPARATSHRABCB11CYP1A2 | |
| SCHEMBL4482427 | 0.78 | TSHR (0.40) | TSHRMMP8 | |
| SCHEMBL3485006 | 0.78 | FBP1 (0.55) | FBP1PPARATSHRABCB11CYP1A2 | |
| SCHEMBL941652 | 0.77 | FBP1 (0.56) | FBP1PPARATSHRABCB11CYP1A2 | |
| SCHEMBL31745119 | 0.77 | FBP1 (0.54) | FBP1PPARATSHRABCB11CYP1A2 | |
| SCHEMBL7981279 | 0.77 | FBP1 (0.54) | FBP1PPARATSHRABCB11CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449468-B2 | Thiazole and oxazole derivatives as activators of human peroxisome proliferator activated receptors | SMITHKLINE BEECHAM CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-20070225294-A1 | THIAZOLE AND OXAZOLE DERIVATIVES AS ACTIVATORS OF HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS | BANKER PIERETTE | 2007-09-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225294-A1 | THIAZOLE AND OXAZOLE DERIVATIVES AS ACTIVATORS OF HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS | GPR119, PPARA, PPARG | FBP1 1697/4885PPARA 2/4885TSHR 25/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.