Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.51 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.51 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.50 |
| ▸ | LTA4H | P09960 | 2/20 | 0.47 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.47 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | HTR6 | P50406 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL417613 | 0.90 | MET (0.61) | METMAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL413547 | 0.80 | MAPT (0.46) | METMAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL721730 | 0.80 | MAP2K1 (0.50) | METMAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL410440 | 0.79 | MAPT (0.45) | METMAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL858715 | 0.78 | MET (0.58) | METMAPTMAPK1L3MBTL1FGFR1 | |
| SCHEMBL10293120 | 0.78 | GPR84 (0.56) | METFGFR1FGFR4GPR84HTR2A | |
| SCHEMBL415278 | 0.76 | FGFR1 (0.64) | METMAPTTDP1L3MBTL1FGFR1 | |
| SCHEMBL27731389 | 0.75 | MAPT (0.46) | METMAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL416501 | 0.75 | MET (0.50) | METGPR84LTA4HPLA2G2ATRPM8 | |
| SCHEMBL19612191 | 0.75 | MAPT (1.00) | MAPTMAPK1TDP1L3MBTL1LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008080015-A2 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON, INC. (US) | 2008-07-03 | — | — | WO | disclosed |
| WO-2007002325-A1 | PYRROLO[2,3-B] PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | PLEXXIKON, INC. (US) | 2007-01-04 | — | — | WO | disclosed |