Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.53 |
| ▸ | CDK9 | P50750 | 1/20 | 0.53 |
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 6/20 | 0.45 |
| ▸ | RAB9A | P51151 | 6/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31735888 | 0.85 | KDM4E (0.51) | KDM4EALDH1A1LMNACCNT1CDK9 | |
| SCHEMBL23302246 | 0.85 | KDM4E (0.51) | KDM4EALDH1A1LMNACCNT1CDK9 | |
| SCHEMBL30390474 | 0.85 | KDM4E (0.51) | KDM4EALDH1A1LMNACCNT1CDK9 | |
| SCHEMBL24463160 | 0.85 | KDM4E (0.51) | KDM4EALDH1A1LMNACCNT1CDK9 | |
| SCHEMBL13916682 | 0.84 | KDM4E (0.69) | KDM4EALDH1A1LMNACHRNB2CHRNA4 | |
| SCHEMBL13916685 | 0.82 | KDM4E (0.67) | KDM4EALDH1A1LMNACHRNB2CHRNA4 | |
| SCHEMBL11532299 | 0.82 | KDM4E (0.49) | KDM4EALDH1A1LMNACCNT1CDK9 | |
| SCHEMBL13035825 | 0.82 | KDM4E (0.49) | KDM4EALDH1A1LMNACCNT1CDK9 | |
| SCHEMBL6492005 | 0.82 | KDM4E (0.49) | KDM4EALDH1A1LMNACCNT1CDK9 | |
| SCHEMBL23679807 | 0.81 | SMN1; SMN2 (0.55) | KDM4EALDH1A1LMNACCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8877791-B2 | Inhibitors of pyruvate kinase and methods of treating disease | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) | 2014-11-04 | — | — | US | disclosed |
| US-8716491-B2 | Benzimidazolium dyes and their use as fluorescent chemosensors | NEW YORK UNIVERSITY (US) | 2014-05-06 | — | — | US | disclosed |
| EP-1377642-B1 | COLORING COMPOSITION FOR IMAGE FORMATION AND METHOD FOR IMPROVING OZONE RESISTANCE OF COLOR IMAGE | FUJIFILM CORP (JP) | 2013-01-09 | — | — | EP | disclosed |
| US-20100099726-A1 | INHIBITORS OF PYRUVATE KINASE AND METHODS OF TREATING DISEASE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-04-22 | — | — | US | disclosed |
| US-20080160521-A1 | BENZIMIDAZOLIUM DYES AND THEIR USE AS FLUORESCENT CHEMOSENSORS | NEW YORK UNIVERSITY (US) | 2008-07-03 | — | — | US | disclosed |
| US-6291203-B1 | UNSYMMETRICAL FLUORESCENT DYES FOR ORGANELLES | MOLECULAR PROBES, INC. | 2001-09-18 | — | — | US | disclosed |
| US-4883880-A | Process for the preparation of sulfoalkyl quaternary salts and for the production of alkane sultones | AGFA-GEVAERT AKTIENGESSELLSCHAFT (DE) | 1989-11-28 | — | — | US | disclosed |
| US-4539408-A | Process for the preparation of sulphoalkyl quaternary salts | AGFA-GEVAERT AKTIENGESELLSCHAFT (DE) | 1985-09-03 | — | — | US | disclosed |
| US-4504668-A | Process for the preparation of N-sulfoalkyl quaternary salts of nitrogen heterocyclics | AGFA-GEVAERT AKTIENGESELLSCHAFT (DE) | 1985-03-12 | — | — | US | disclosed |
| EP-0064667-B1 | PROCESS FOR THE PREPARATION OF SULFOALKYL QUATERNARY SALTS | Agfa-Gevaert AG (DE) | 1984-11-28 | — | — | EP | disclosed |
| EP-0055428-B1 | BIS-(3-SULFOPROPYL)ETHERS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ALKYLATING AGENTS FOR ORGANIC BASES | Agfa-Gevaert AG (DE) | 1984-03-14 | — | — | EP | disclosed |
| EP-0034279-B1 | SULFOALKYLATING AGENTS, PROCESS FOR THEIR PREPARATION AND THEIR USE IN THE MANUFACTURE OF QUANTERNARY SULFOALKYL SALTS | Agfa-Gevaert AG (DE) | 1983-06-22 | — | — | EP | disclosed |
| EP-0064667-A1 | Process for the preparation of sulfoalkyl quaternary salts | Agfa-Gevaert AG (DE) | 1982-11-17 | — | — | EP | disclosed |
| EP-0055428-A1 | Bis-(3-sulfopropyl)ethers, process for their preparation and their use as alkylating agents for organic bases | Agfa-Gevaert AG (DE) | 1982-07-07 | — | — | EP | disclosed |
| EP-0034279-A2 | Sulfoalkylating agents, process for their preparation and their use in the manufacture of quanternary sulfoalkyl salts | Agfa-Gevaert AG (DE) | 1981-08-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080160521-A1 | BENZIMIDAZOLIUM DYES AND THEIR USE AS FLUORESCENT CHEMOSENSORS | IK, C9, CBR3 | KDM4E 3085/4885ALDH1A1 760/4885LMNA 975/4885 |
| US-20100099726-A1 | INHIBITORS OF PYRUVATE KINASE AND METHODS OF TREATING DISEASE | PDK1, PDK4, PDK3 | KDM4E 1017/4885ALDH1A1 978/4885LMNA 2446/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.