Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | SLC6A19 | Q695T7 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8364996 | 1.00 | SMN1; SMN2 (0.40) | SMN1; SMN2NPC1RAB9ARECQLHSD17B3 | |
| SCHEMBL4886669 | 0.89 | AKR1C3 (0.43) | SMN1; SMN2NPC1RAB9ARECQLHSD17B3 | |
| SCHEMBL4886670 | 0.89 | AKR1C3 (0.43) | SMN1; SMN2NPC1RAB9ARECQLHSD17B3 | |
| SCHEMBL4886664 | 0.89 | AKR1C3 (0.43) | SMN1; SMN2NPC1RAB9ARECQLHSD17B3 | |
| SCHEMBL2808687 | 0.87 | MIF (0.40) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL2808690 | 0.87 | MIF (0.40) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL13125661 | 0.87 | MIF (0.40) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL5140506 | 0.85 | NPSR1 (0.38) | SMN1; SMN2NPC1RAB9ARECQLMAPT | |
| SCHEMBL8364952 | 0.85 | NPSR1 (0.38) | SMN1; SMN2NPC1RAB9ARECQLMAPT | |
| SCHEMBL5140504 | 0.85 | NPSR1 (0.38) | SMN1; SMN2NPC1RAB9ARECQLMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080275018-A1 | ANTIBACTERIAL AMIDE-MACROCYCLES V | AICURIS GMBH & CO. KG (DE) | 2008-11-06 | — | — | US | disclosed |
| US-20080275018-A1 | ANTIBACTERIAL AMIDE-MACROCYCLES V | AICURIS GMBH & CO. KG (DE) | 2008-11-06 | — | — | US | disclosed |
| EP-1869068-A1 | ANTIBACTERIAL AMIDE-MACROCYCLES V | AiCuris GmbH & Co. KG (DE) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006103015-A1 | ANTIBACTERIAL AMIDE-MACROCYCLES V | AICURIS GMBH & CO. KG (DE) | 2006-10-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080275018-A1 | ANTIBACTERIAL AMIDE-MACROCYCLES V | ARG1, HRH3, H1-0 | SMN1; SMN2 4001/4885NPC1 2382/4885RAB9A 2388/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.