Sugi Predict

Sugi Predict / Compounds / SCHEMBL488377

SCHEMBL488377

SCHEMBL488377

Nc1ncc(-c2cccc(NS(=O)(=O)CCN3CCOCC3)c2)nc1OCc1c(F)ccc(F)c1Cl

nearest known ligand 0.47

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ MAP4K4 O95819 3/20 0.47
▸ CSF1R P07333 2/20 0.40
▸ JAK3 P52333 1/20 0.38
▸ MET P08581 4/20 0.38
▸ TYRO3 Q06418 1/20 0.37
▸ ALOX5AP P20292 1/20 0.37
▸ FEN1 P39748 1/20 0.37
▸ KDR P35968 1/20 0.37
▸ ATR Q13535 5/20 0.36
▸ PIK3CD O00329 1/20 0.36
▸ PIK3CA P42336 1/20 0.36
▸ PIK3CB P42338 1/20 0.36
▸ PIK3CG P48736 1/20 0.36
▸ USP2 O75604 1/20 0.35
▸ ALDH1A1 P00352 1/20 0.35
▸ CYP1A2 P05177 1/20 0.35
▸ CYP3A4 P08684 1/20 0.35
▸ CLK4 Q9HAZ1 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30453752 1.00 MAP4K4 (0.47) MAP4K4CSF1RJAK3METTYRO3
SCHEMBL30454893 0.93 MAP4K4 (0.45) MAP4K4CSF1RMETTYRO3ATR
SCHEMBL487930 0.93 MAP4K4 (0.45) MAP4K4CSF1RMETTYRO3ATR
SCHEMBL488090 0.93 MAP4K4 (0.46) MAP4K4CSF1RJAK3METTYRO3
SCHEMBL30452819 0.93 MAP4K4 (0.46) MAP4K4CSF1RJAK3METTYRO3
SCHEMBL488465 0.91 MAP4K4 (0.46) MAP4K4CSF1RMETALOX5APFEN1
SCHEMBL30454955 0.91 MAP4K4 (0.46) MAP4K4CSF1RMETALOX5APFEN1
SCHEMBL30452628 0.91 TYRO3 (0.40) MAP4K4CSF1RMETTYRO3ATR
SCHEMBL488554 0.91 TYRO3 (0.40) MAP4K4CSF1RMETTYRO3ATR
SCHEMBL487838 0.89 CSF1R (0.40) MAP4K4CSF1RMETTYRO3ATR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8106197-B2 Aminoheteroaryl compounds as protein kinase inhibitors PFIZER INC. (US) 2012-01-31 — — US disclosed
US-8106197-B2 Aminoheteroaryl compounds as protein kinase inhibitors PFIZER INC. (US) 2012-01-31 — — US disclosed
US-8106197-B2 Aminoheteroaryl compounds as protein kinase inhibitors PFIZER INC. (US) 2012-01-31 — — US disclosed
US-7230098-B2 2-amino- pyridines and pyrazines additionally substituted witn one or more carbocyclic or heterocyclic groups, e.g., 4-[6-amino-5-(2,6-dichloro-benzyloxy)-pyridin-3-yl]-phenol, for treating many kinds of cancer SUGEN, INC. (US) 2007-06-12 — — US disclosed
US-7230098-B2 2-amino- pyridines and pyrazines additionally substituted witn one or more carbocyclic or heterocyclic groups, e.g., 4-[6-amino-5-(2,6-dichloro-benzyloxy)-pyridin-3-yl]-phenol, for treating many kinds of cancer SUGEN, INC. (US) 2007-06-12 — — US disclosed
US-20070072874-A1 Aminoheteroaryl compounds as protein kinase inhibitors SUGEN, INC. 2007-03-29 — — US disclosed
US-20070072874-A1 Aminoheteroaryl compounds as protein kinase inhibitors SUGEN, INC. 2007-03-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070072874-A1 Aminoheteroaryl compounds as protein kinase inhibitors MET, MAP4K1, MAP4K2 MAP4K4 10/4885CSF1R 757/4885JAK3 516/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.