Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.54 |
| ▸ | MET | P08581 | 16/20 | 0.53 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.46 |
| ▸ | MAP3K1 | Q13233 | 1/20 | 0.46 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.46 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.46 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | INSR | P06213 | 1/20 | 0.42 |
| ▸ | NPM1 | P06748 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30452942 | 1.00 | MAP4K3 (0.54) | MAP4K3METMAP4K2MAP3K1AAK1 | |
| SCHEMBL10216416 | 1.00 | MAP4K3 (0.54) | MAP4K3METMAP4K2MAP3K1AAK1 | |
| SCHEMBL30452953 | 0.95 | MAP4K3 (0.48) | MAP4K3METMAP4K2MAP3K1AAK1 | |
| SCHEMBL488804 | 0.95 | MAP4K3 (0.48) | MAP4K3METMAP4K2MAP3K1AAK1 | |
| SCHEMBL10216410 | 0.95 | MAP4K3 (0.48) | MAP4K3METMAP4K2MAP3K1AAK1 | |
| SCHEMBL488848 | 0.88 | MET (0.61) | MAP4K3METMAP4K2MAP3K1AAK1 | |
| SCHEMBL30453713 | 0.88 | MET (0.61) | MAP4K3METMAP4K2MAP3K1AAK1 | |
| SCHEMBL10215653 | 0.87 | MET (0.65) | MAP4K3METMAP4K2MAP3K1AAK1 | |
| SCHEMBL30454989 | 0.87 | MET (0.65) | MAP4K3METMAP4K2MAP3K1AAK1 | |
| SCHEMBL487918 | 0.87 | MET (0.65) | MAP4K3METMAP4K2MAP3K1AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4695588-B2 | — | — | 2011-06-08 | — | — | JP | claimed |
| US-8106197-B2 | Aminoheteroaryl compounds as protein kinase inhibitors | PFIZER INC. (US) | 2012-01-31 | — | — | US | disclosed |