Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.48 |
| ▸ | MET | P08581 | 13/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.40 |
| ▸ | MAP3K1 | Q13233 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.40 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.40 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10216410 | 1.00 | MAP4K3 (0.48) | MAP4K3METKCNH2CHEK2ATR | |
| SCHEMBL488804 | 1.00 | MAP4K3 (0.48) | MAP4K3METKCNH2CHEK2ATR | |
| SCHEMBL488390 | 0.95 | MAP4K3 (0.54) | MAP4K3METCHEK2MAP4K2MAP3K1 | |
| SCHEMBL10216416 | 0.95 | MAP4K3 (0.54) | MAP4K3METCHEK2MAP4K2MAP3K1 | |
| SCHEMBL30452942 | 0.95 | MAP4K3 (0.54) | MAP4K3METCHEK2MAP4K2MAP3K1 | |
| SCHEMBL488690 | 0.88 | KCNH2 (0.55) | MAP4K3METKCNH2CHEK2ATR | |
| SCHEMBL488688 | 0.88 | KCNH2 (0.55) | MAP4K3METKCNH2CHEK2ATR | |
| SCHEMBL30452472 | 0.88 | KCNH2 (0.55) | MAP4K3METKCNH2CHEK2ATR | |
| SCHEMBL488801 | 0.88 | MET (0.55) | MAP4K3METCHEK2ATRMAP4K2 | |
| SCHEMBL30453393 | 0.88 | MET (0.55) | MAP4K3METCHEK2ATRMAP4K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4599890-A2 | SUNITINIB FOR PREVENTING AND/OR TREATING AMYOTROPHIC LATERAL SCLEROSIS | Kyoto University (JP) | 2025-08-13 | — | — | EP | disclosed |
| CN-113181362-B | Medicament for preventing and/or treating amyotrophic lateral sclerosis | 国立大学法人京都大学 | 2023-06-13 | — | — | CN | disclosed |