Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 2/20 | 0.53 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.50 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.50 |
| ▸ | SYK | P43405 | 1/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.48 |
| ▸ | CTSS | P25774 | 1/20 | 0.48 |
| ▸ | CPB1 | P15086 | 1/20 | 0.47 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.47 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.47 |
| ▸ | CAPN2 | P17655 | 1/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4883932 | 0.91 | SYK (0.59) | KLK7KLK5MAPTSIRT2SIRT1 | |
| SCHEMBL1024654 | 0.89 | KLK7 (0.49) | KLK7KLK5MAPTSIRT2SIRT1 | |
| SCHEMBL4857149 | 0.87 | MAPT (0.58) | KLK7KLK5MAPTSIRT2SIRT1 | |
| SCHEMBL25502674 | 0.85 | MAPT (0.60) | KLK7KLK5MAPTSIRT2SIRT1 | |
| SCHEMBL30902907 | 0.85 | MAPT (0.65) | KLK7KLK5MAPTSIRT2SIRT1 | |
| SCHEMBL30902797 | 0.85 | MAPT (0.62) | KLK7KLK5MAPTSIRT2SIRT1 | |
| SCHEMBL14320294 | 0.84 | SYK (0.57) | KLK7KLK5MAPTSIRT2SIRT1 | |
| SCHEMBL14320293 | 0.84 | SYK (0.57) | KLK7KLK5MAPTSIRT2SIRT1 | |
| SCHEMBL5996732 | 0.84 | CTSK (0.61) | KLK7KLK5MAPTCTSLCTSS | |
| SCHEMBL8646821 | 0.83 | HTT (0.56) | SIRT2SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080275018-A1 | ANTIBACTERIAL AMIDE-MACROCYCLES V | AICURIS GMBH & CO. KG (DE) | 2008-11-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080275018-A1 | ANTIBACTERIAL AMIDE-MACROCYCLES V | ARG1, HRH3, H1-0 | KLK7 4300/4885KLK5 4270/4885MAPT 4840/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.