Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 11/20 | 0.48 |
| ▸ | SCNN1A | P37088 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | GLA | P06280 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MAOA | P21397 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.48 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.48 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4415799 | 1.00 | PLAU (0.48) | PLAUSCNN1AKDM4EALDH1A1GLA | |
| SCHEMBL4885153 | 1.00 | PLAU (0.48) | PLAUSCNN1AKDM4EALDH1A1GLA | |
| SCHEMBL4883733 | 1.00 | PLAU (0.48) | PLAUSCNN1AKDM4EALDH1A1GLA | |
| SCHEMBL5037182 | 1.00 | PLAU (0.48) | PLAUSCNN1AKDM4EALDH1A1GLA | |
| SCHEMBL4412099 | 1.00 | PLAU (0.48) | PLAUSCNN1AKDM4EALDH1A1GLA | |
| SCHEMBL5034626 | 0.94 | PLAU (0.46) | PLAUSCNN1AKDM4EALDH1A1GLA | |
| Hydrochloric Acid SCHEMBL4693836 | 0.86 | KDM4E (0.62) | PLAUSCNN1AKDM4EALDH1A1GLA | |
| Bromide SCHEMBL4789645 | 0.86 | PLAU (0.60) | PLAUSCNN1AKDM4EALDH1A1GLA | |
| SCHEMBL938196 | 0.86 | SCNN1A (0.49) | SCNN1A | |
| SCHEMBL938701 | 0.86 | SCNN1A (0.44) | PLAUSCNN1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080200476-A1 | ALAPHATIC PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS | PARION SCIENCES, INC. (US) | 2008-08-21 | — | — | US | disclosed |
| US-7375107-B2 | Such as N-(6-aminohexyl)-N'-(3,5-diamino-6-chloropyrazine-2-carbonyl)guanidine Dihydrochloride; for hydration of mucosal surfaces, treating chronic bronchitis, cystic fibrosis, sinusitis, vaginal dryness, dry eye, esophogitis, emphysema, and pneumonia | PARION SCIENCES, INC. (US) | 2008-05-20 | — | — | US | disclosed |
| US-20050090505-A1 | Methods of reducing risk of infection from pathogens | JOHNSON MICHAEL R (US) | 2005-04-28 | — | — | US | disclosed |
| US-20050080092-A1 | Alaphatic pyrazinoylguanidine sodium channel blockers | PARION SCIENCES, INC. (US) | 2005-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050080092-A1 | Alaphatic pyrazinoylguanidine sodium channel blockers | KCNH1, CACNA1B, CACNA1C | PLAU 2000/4885SCNN1A 66/4885KDM4E 3281/4885 |
| US-20050090505-A1 | Methods of reducing risk of infection from pathogens | KCNN3, KCNN1, KCNN2 | PLAU 1449/4885SCNN1A 14/4885KDM4E 4810/4885 |
| US-20080200476-A1 | ALAPHATIC PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS | KCNH1, CACNA1B, CACNA1C | PLAU 2000/4885SCNN1A 66/4885KDM4E 3281/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.