Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 11/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GMNN | O75496 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23869688 | 0.82 | HDAC1 (0.41) | HDAC1KIF11ALDH1A1MAPTMEN1 | |
| SCHEMBL29483463 | 0.81 | MAPT (0.42) | HDAC1KIF11ALDH1A1MAPTMEN1 | |
| SCHEMBL11077132 | 0.81 | RECQL (0.59) | PDE4APDE4BPDE4CPDE4DHDAC1 | |
| SCHEMBL11077135 | 0.81 | RECQL (0.59) | PDE4APDE4BPDE4CPDE4DHDAC1 | |
| SCHEMBL14189755 | 0.77 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL26568181 | 0.77 | MAPT (0.37) | HDAC1KIF11ALDH1A1MAPTMEN1 | |
| SCHEMBL8999111 | 0.77 | CYP1A1 (0.48) | PDE4APDE4BPDE4CPDE4DKIF11 | |
| SCHEMBL8999105 | 0.77 | CYP1A1 (0.48) | PDE4APDE4BPDE4CPDE4DKIF11 | |
| SCHEMBL7231328 | 0.72 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL4927520 | 0.72 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080293722-A1 | Ion Channel Modulators | WYETH (US) | 2008-11-27 | — | — | US | disclosed |
| US-20080293722-A1 | Ion Channel Modulators | WYETH (US) | 2008-11-27 | — | — | US | disclosed |
| US-20080293722-A1 | Ion Channel Modulators | WYETH (US) | 2008-11-27 | — | — | US | disclosed |
| EP-1725523-A4 | ION CHANNEL MODULATORS | WYETH CORP (US) | 2007-10-10 | — | — | EP | disclosed |
| EP-1725523-A1 | ION CHANNEL MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2006-11-29 | — | — | EP | disclosed |
| WO-2005090291-A1 | ION CHANNEL MODULATORS | WYETH (US) | 2005-09-29 | — | — | WO | disclosed |
| WO-2005090291-A1 | ION CHANNEL MODULATORS | WYETH (US) | 2005-09-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293722-A1 | Ion Channel Modulators | CACNA1B, CACNA1C, TRPV1 | PDE4A 1012/4885PDE4B 1094/4885PDE4C 980/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.