Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 15/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 15/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 15/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 15/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALPG | P10696 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5948110 | 0.89 | LTA4H (0.52) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL5948108 | 0.89 | LTA4H (0.52) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL5947809 | 0.87 | PARP10 (0.44) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL5947811 | 0.87 | PARP10 (0.44) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL4733996 | 0.86 | PDE4A (0.73) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL4733999 | 0.86 | PDE4A (0.73) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL4734003 | 0.86 | PDE4A (0.73) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL5948079 | 0.83 | PTGS2 (0.63) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4918109 | 0.83 | PTGS2 (0.63) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5947873 | 0.83 | HDAC2 (0.44) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080280904-A1 | N-Substituted Pyridinone or Pyrimidinone Compounds Useful as Soluble Epoxide Hydrolase Inhibitors | ELDRUP ANNE BETTINA | 2008-11-13 | — | — | US | disclosed |
| EP-1640359-A2 | ANTICONVULSANT AND CENTRAL NERVOUS SYSTEM-ACTIVE BIS(FLUOROPHENYL)ALKYLAMIDES | NPS PHARMACEUTICALS, INC. (US) | 2006-03-29 | — | — | EP | disclosed |
| EP-1042275-B1 | ANTICONVULSANT AND CENTRAL NERVOUS SYSTEM-ACTIVE BIS(FLUOROPHENYL)ALKYLAMIDES | NPS PHARMA INC (US) | 2005-11-09 | — | — | EP | disclosed |
| US-20030199589-A1 | Anticonvulsant and central nervous system-depressing bis (fluorophenyl) alkylamides and their uses | NPS PHARMACEUTICALS, INC. | 2003-10-23 | — | — | US | disclosed |
| US-6617358-B1 | Also bis(optionally chloro- or fluoro-substitutedphenyl)alkylcarboxy acids and esters | NPS PHARMACEUTICALS, INC. | 2003-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080280904-A1 | N-Substituted Pyridinone or Pyrimidinone Compounds Useful as Soluble Epoxide Hydrolase Inhibitors | EPHX1, EPHX2, DOHH | PDE4A 1208/4885PDE4B 1661/4885PDE4C 1486/4885 |
| US-20030199589-A1 | Anticonvulsant and central nervous system-depressing bis (fluorophenyl) alkylamides and their uses | GABRE, GABRA2, GABRB2 | PDE4A 2909/4885PDE4B 3031/4885PDE4C 3725/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.