SCHEMBL4886435

SCHEMBL4886435

COc1ccnc(-c2ccccn2)c1OC

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 6/20 0.48
NPC1 O15118 4/20 0.48
MAPT P10636 3/20 0.48
ALDH1A1 P00352 3/20 0.48
TP53 P04637 3/20 0.48
RAB9A P51151 2/20 0.48
KDM4E B2RXH2 6/20 0.48
L3MBTL1 Q9Y468 5/20 0.48
LMNA P02545 3/20 0.48
POLB P06746 2/20 0.48
HTT P42858 2/20 0.48
TDP1 Q9NUW8 1/20 0.48
TGFBR1 P36897 2/20 0.46
ERN1 O75460 1/20 0.43
CYP1A2 P05177 1/20 0.43
CCR1 P32246 1/20 0.43
CCR5 P51681 1/20 0.43
CCR8 P51685 1/20 0.43
METAP1 P53582 1/20 0.43
BLM P54132 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29707162 0.98 SMN1; SMN2 (0.47) SMN1; SMN2NPC1MAPTALDH1A1TP53
SCHEMBL7037994 0.80 SMN1; SMN2 (0.51) SMN1; SMN2NPC1MAPTALDH1A1TP53
SCHEMBL30867783 0.80 SMN1; SMN2 (0.51) SMN1; SMN2NPC1MAPTALDH1A1TP53
SCHEMBL11363007 0.79 IDO1 (0.45) SMN1; SMN2ALDH1A1KDM4EL3MBTL1LMNA
SCHEMBL12317970 0.77 ALDH1A1 (0.65) SMN1; SMN2NPC1MAPTALDH1A1KDM4E
SCHEMBL29496942 0.77 ALDH1A1 (0.65) SMN1; SMN2NPC1MAPTALDH1A1KDM4E
SCHEMBL9847563 0.76 ATM (0.39) SMN1; SMN2NPC1ALDH1A1RAB9AKDM4E
SCHEMBL8501500 0.76 SMN1; SMN2 (0.51) SMN1; SMN2NPC1MAPTALDH1A1TP53
SCHEMBL29496937 0.76 SMN1; SMN2 (0.66) SMN1; SMN2NPC1MAPTALDH1A1TP53
SCHEMBL5463881 0.76 SMN1; SMN2 (0.66) SMN1; SMN2NPC1MAPTALDH1A1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 144 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120058855-A Preparation method of Mebamamide C 深圳连续制药科技有限公司 2025-05-30 CN claimed
CN-119684069-A Method for preparing beta-trichloromethyl butyl ester or amide 中国科学院大连化学物理研究所 2025-03-25 CN claimed
CN-119661396-A Preparation method of gamma-amino acid derivative or dipeptide 中国科学院大连化学物理研究所 2025-03-21 CN claimed
CN-119264059-A Preparation method of Olaparib intermediate 山东新时代药业有限公司 2025-01-07 CN claimed
CN-116283632-B Beta-amino-alpha-halogenated/selenocarboxylic acid ester and synthetic method and application thereof 吉首大学 2024-10-22 CN claimed
CN-117924161-A Preparation of pH response type artificial channel with high selectivity for inhibiting growth of intestinal cancer cell HCT116 厦门大学 2024-04-26 CN claimed
CN-114539168-B Method for synthesizing Piraglatin and analogues thereof 武汉大学 2023-11-17 CN claimed
CN-116947709-A Synthesis method of beta-arylvinyl sulfonyl fluoride compound 江南大学 2023-10-27 CN claimed
CN-116874395-A Visible light-promoted amino acid alpha-position alkylation modification method 华中科技大学 2023-10-13 CN claimed
CN-114832862-B Catalytic composition for coupling reaction and application of catalytic composition in preparation of isoquinoline-1, 3-dione compounds 中国药科大学 2023-06-30 CN claimed
CN-115073334-A Synthesis method of 4,4' -thiobis (6-tert-butyl-m-cresol) 江苏极易新材料有限公司 2022-09-20 CN claimed
CN-114957120-A Alkenyl homopiperidine compound and preparation method thereof 苏州大学 2022-08-30 CN claimed
CN-114853568-A Preparation method of 4,4,5,5, 5-penta-fluoropentanol 辽宁迪诺医药科技有限公司 2022-08-05 CN claimed
CN-114832862-A Catalytic composition for coupling reaction and application thereof in preparation of isoquinoline-1, 3-diketone compounds 中国药科大学 2022-08-02 CN claimed
CN-114539168-A Method for synthesizing Piraglianin and analogues thereof 武汉大学 2022-05-27 CN claimed
CN-114516779-A Method for selective functionalization of bicycloheptatriene-rubine (DHR) and derivatization application thereof 中国科学院化学研究所 2022-05-20 CN claimed
CN-114384135-A Conductive nano-material glucose sensing material and preparation method and application thereof 四川大学 2022-04-22 CN claimed
CN-114031566-A Preparation method of stable isotope labeled diazepam internal standard reagent 谱同生物医药科技(常州)有限公司 2022-02-11 CN claimed
CN-107628926-B Preparation method of monofluoroethyl substituted aromatic compound 四川理工学院 2020-07-28 CN claimed
CN-1852882-A Process for reduction of carbon dioxide with organometallic complex JAPAN SCIENCE & TECH AGENCY (JP) 2006-10-25 CN claimed