Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 8/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | HTT | P42858 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 2/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4886798 | 0.91 | LMNA (0.56) | LMNASMN1; SMN2KMT2AHTTMEN1 | |
| SCHEMBL4894694 | 0.84 | LMNA (0.53) | LMNASMN1; SMN2KMT2AHTTMEN1 | |
| SCHEMBL4886782 | 0.83 | LMNA (0.58) | LMNASMN1; SMN2KMT2AHTTMEN1 | |
| SCHEMBL26769715 | 0.82 | LMNA (0.64) | LMNASMN1; SMN2KMT2AHTTMEN1 | |
| SCHEMBL18986533 | 0.80 | LMNA (0.55) | LMNASMN1; SMN2KMT2AHTTMEN1 | |
| SCHEMBL3454936 | 0.79 | LMNA (0.73) | LMNASMN1; SMN2KMT2AHTTMEN1 | |
| SCHEMBL3484826 | 0.78 | GAA (0.59) | LMNASMN1; SMN2KMT2AHTTMEN1 | |
| SCHEMBL599787 | 0.78 | GAA (0.59) | LMNASMN1; SMN2KMT2AHTTMEN1 | |
| SCHEMBL4884706 | 0.77 | LMNA (0.47) | LMNASMN1; SMN2KMT2AHTTMEN1 | |
| SCHEMBL12169294 | 0.77 | LMNA (0.52) | LMNASMN1; SMN2KMT2AHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2008518889-A | — | — | 2008-06-05 | — | — | JP | claimed |
| EP-1812405-A1 | NOVEL BRADYKININ B1 ANTAGONISTS, METHOD FOR PRODUCING THE SAME AND THE USE THEREOF AS DRUGS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-08-01 | — | — | EP | claimed |
| WO-2006048209-A1 | NOVEL BRADYKININ B1 ANTAGONISTS, METHOD FOR PRODUCING THE SAME AND THE USE THEREOF AS DRUGS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-05-11 | — | — | WO | claimed |