Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4886802 | 0.92 | LMNA (0.48) | LMNASMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL4886776 | 0.83 | LMNA (0.67) | LMNASMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL4894694 | 0.76 | LMNA (0.53) | LMNASMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL4884706 | 0.75 | LMNA (0.47) | LMNASMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL4886798 | 0.74 | LMNA (0.56) | LMNASMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL5218879 | 0.73 | VCAM1 (0.48) | LMNASMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL5209884 | 0.68 | LMNA (0.46) | LMNASMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL4894187 | 0.68 | PKM (0.49) | LMNASMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL8411797 | 0.68 | SERPINE1 (0.52) | LMNAALDH1A1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL4891235 | 0.67 | LMNA (0.41) | LMNASMN1; SMN2KMT2APOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2008518889-A | — | — | 2008-06-05 | — | — | JP | claimed |
| EP-1812405-A1 | NOVEL BRADYKININ B1 ANTAGONISTS, METHOD FOR PRODUCING THE SAME AND THE USE THEREOF AS DRUGS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-08-01 | — | — | EP | claimed |
| WO-2006048209-A1 | NOVEL BRADYKININ B1 ANTAGONISTS, METHOD FOR PRODUCING THE SAME AND THE USE THEREOF AS DRUGS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-05-11 | — | — | WO | claimed |