Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GFER | P55789 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.33 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17716402 | 0.84 | SCN9A (0.36) | SMN1; SMN2KMT2AALDH1A1TDP1RAB9A | |
| SCHEMBL855213 | 0.80 | SMN1; SMN2 (0.57) | SMN1; SMN2KMT2ALMNAALDH1A1KDM4E | |
| SCHEMBL4890454 | 0.78 | SMN1; SMN2 (0.50) | SMN1; SMN2KMT2ALMNAALDH1A1KDM4E | |
| SCHEMBL1118859 | 0.78 | SMN1; SMN2 (0.50) | SMN1; SMN2KMT2ALMNAALDH1A1KDM4E | |
| SCHEMBL5988033 | 0.77 | SMN1; SMN2 (0.49) | SMN1; SMN2KMT2ALMNAALDH1A1KDM4E | |
| SCHEMBL14825340 | 0.76 | SMN1; SMN2 (0.53) | SMN1; SMN2KMT2ALMNAALDH1A1KDM4E | |
| SCHEMBL4883603 | 0.76 | SMN1; SMN2 (0.53) | SMN1; SMN2KMT2ALMNAALDH1A1KDM4E | |
| SCHEMBL10833045 | 0.75 | SMN1; SMN2 (0.42) | SMN1; SMN2KMT2ALMNAALDH1A1KDM4E | |
| Formaldehyde SCHEMBL28793964 | 0.75 | SMN1; SMN2 (0.47) | SMN1; SMN2KMT2ALMNAALDH1A1KDM4E | |
| SCHEMBL5177254 | 0.74 | HSD17B10 (0.43) | SMN1; SMN2KMT2AKDM4ERAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080015202-A1 | Thiazole Derivatives Having Vap-1 Inhibitory Activity | ASTELLAS PHARMA INC. (JP) | 2008-01-17 | — | — | US | disclosed |
| EP-1791835-A2 | THIAZOLE DERIVATIVES HAVING VAP-1 INHIBITORY ACTIVITY | Astellas Pharma Inc. (JP) | 2007-06-06 | — | — | EP | disclosed |
| WO-2006028269-A2 | THIAZOLE DERIVATIVES HAVING VAP-1 IHIBITORY ACTIVITY | ASTELLAS PHARMA INC. (JP) | 2006-03-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080015202-A1 | Thiazole Derivatives Having Vap-1 Inhibitory Activity | VCAM1, VAPB, VAPA | SMN1; SMN2 2277/4885KMT2A 4199/4885LMNA 2418/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.