Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 14/20 | 1.00 |
| ▸ | THRB | P10828 | 14/20 | 1.00 |
| ▸ | ESR1 | P03372 | 1/20 | 0.77 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.77 |
| ▸ | PGR | P06401 | 1/20 | 0.77 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.77 |
| ▸ | AR | P10275 | 1/20 | 0.77 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.53 |
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.53 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4363817 | 0.87 | THRA (0.77) | THRATHRBESR1NR3C1PGR | |
| SCHEMBL5072110 | 0.87 | THRA (0.81) | THRATHRBESR1NR3C1PGR | |
| SCHEMBL4898980 | 0.87 | THRA (1.00) | THRATHRBESR1NR3C1PGR | |
| SCHEMBL5717986 | 0.86 | THRA (0.74) | THRATHRBESR1NR3C1PGR | |
| SCHEMBL4896873 | 0.86 | THRA (1.00) | THRATHRBESR1NR3C1PGR | |
| SCHEMBL4891205 | 0.85 | THRA (1.00) | THRATHRBESR1NR3C1PGR | |
| SCHEMBL4898421 | 0.85 | THRA (0.77) | THRATHRBESR1NR3C1PGR | |
| SCHEMBL4898968 | 0.85 | THRA (0.77) | THRATHRBESR1NR3C1PGR | |
| SCHEMBL4362435 | 0.83 | THRA (0.70) | THRATHRBESR1NR3C1PGR | |
| SCHEMBL4896330 | 0.82 | THRA (0.74) | THRATHRBESR1NR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7005538-B1 | Thyroid receptor antagonists for the treatment of cardiac and metabolic disorders | KARO BIO AB (SE) | 2006-02-28 | — | — | US | claimed |
| WO-2001036365-A2 | THYROID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CARDIAC AND METABOLIC DISORDERS | KARO BIO AB (SE) | 2001-05-25 | — | — | WO | claimed |
| US-20080027096-A1 | Novel Pharmaceutical Compositions | KARO BIO AB (SE) | 2008-01-31 | — | — | US | disclosed |
| US-7319163-B2 | Thyroid receptor antagonists for the treatment of cardiac and metabolic disorders | KARO BIO AB (SE) | 2008-01-15 | — | — | US | disclosed |
| US-7319163-B2 | Thyroid receptor antagonists for the treatment of cardiac and metabolic disorders | KARO BIO AB (SE) | 2008-01-15 | — | — | US | disclosed |
| EP-1729756-A2 | NOVEL PHARMACEUTICAL COMPOSITIONS | KARO BIO AB (SE) | 2006-12-13 | — | — | EP | disclosed |
| US-7005538-B1 | Thyroid receptor antagonists for the treatment of cardiac and metabolic disorders | KARO BIO AB (SE) | 2006-02-28 | — | — | US | disclosed |
| US-20050267206-A1 | Thyroid receptor antagonists for the treatment of cardiac and metabolic disorders | MALM JOHAN | 2005-12-01 | — | — | US | disclosed |
| WO-2005094810-A2 | NOVEL PHARMACEUTICAL COMPOSITIONS | KARO BIO AB (SE) | 2005-10-13 | — | — | WO | disclosed |
| WO-2001036365-A2 | THYROID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CARDIAC AND METABOLIC DISORDERS | KARO BIO AB (SE) | 2001-05-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050267206-A1 | Thyroid receptor antagonists for the treatment of cardiac and metabolic disorders | TSHR, THRB, THRA | THRA 3/4885THRB 2/4885ESR1 1026/4885 |
| US-20080027096-A1 | Novel Pharmaceutical Compositions | AR, NR5A1, CYP17A1 | THRA 559/4885THRB 792/4885ESR1 58/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.