SCHEMBL4887320

SCHEMBL4887320

CN1CCN(c2cccc3c2C[C@H](NC(=O)c2ccc(OCC(F)(F)F)nc2)CC3)CC1

nearest known ligand 0.74

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 13/20 0.74
KCNH2 Q12809 11/20 0.74
SCN5A Q14524 10/20 0.74
SLC6A3 Q01959 1/20 0.48
GHSR Q92847 1/20 0.48
HPGDS O60760 2/20 0.45
FAAH O00519 1/20 0.44
GABRA5 P31644 1/20 0.44
MTNR1A P48039 1/20 0.43
MTNR1B P49286 1/20 0.43
EPHX2 P34913 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4788755 0.92 SCN9A (0.75) SCN9AKCNH2SCN5AHPGDSGABRA5
SCHEMBL4789249 0.87 KCNH2 (0.56) SCN9AKCNH2SCN5AHPGDSFAAH
SCHEMBL4789002 0.85 KCNH2 (0.55) SCN9AKCNH2SCN5AGABRA5MTNR1A
SCHEMBL4789086 0.85 KCNH2 (0.54) SCN9AKCNH2SCN5AGABRA5MTNR1A
SCHEMBL7025761 0.83 KCNH2 (0.55) SCN9AKCNH2SCN5AMTNR1AMTNR1B
SCHEMBL6820334 0.83 KCNH2 (0.55) SCN9AKCNH2SCN5AMTNR1AMTNR1B
SCHEMBL6820338 0.83 KCNH2 (0.55) SCN9AKCNH2SCN5AMTNR1AMTNR1B
SCHEMBL840606 0.81 SCN9A (0.72) SCN9AKCNH2SCN5ASLC6A3GHSR
SCHEMBL840982 0.80 SCN9A (0.74) SCN9AKCNH2SCN5ASLC6A3GHSR
SCHEMBL7029805 0.80 KCNH2 (0.54) SCN9AKCNH2SCN5AMTNR1AMTNR1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008130321-A2 NOVEL N-TETRAHYDRONAPHTALENE OR 5-HETEROCYCLYL-CHROMANE OR 8-HETEROCYCLYL-TETRAHYDRONAPHTALENE DERIVATIVES FOR THE TREATMENT OF PAIN ASTRAZENECA AB (SE) 2008-10-30 WO claimed
WO-2008130321-A2 NOVEL N-TETRAHYDRONAPHTALENE OR 5-HETEROCYCLYL-CHROMANE OR 8-HETEROCYCLYL-TETRAHYDRONAPHTALENE DERIVATIVES FOR THE TREATMENT OF PAIN ASTRAZENECA AB (SE) 2008-10-30 WO disclosed