Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.56 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.56 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 2/20 | 0.38 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4887320 | 0.87 | SCN9A (0.74) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL7025761 | 0.87 | KCNH2 (0.55) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL6820338 | 0.87 | KCNH2 (0.55) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL6820334 | 0.87 | KCNH2 (0.55) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL4788895 | 0.85 | KCNH2 (0.49) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL7030282 | 0.84 | MEN1 (0.55) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL7031232 | 0.84 | MEN1 (0.55) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL4788755 | 0.84 | SCN9A (0.75) | KCNH2SCN9ASCN5AHPGDS | |
| SCHEMBL7029805 | 0.84 | KCNH2 (0.54) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL7019156 | 0.84 | KCNH2 (0.54) | KCNH2SCN9ASCN5AMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130323-A1 | NOVEL 8-PIPERAZINE-TETRAHYDRONAPHTALENE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |