Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.55 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.55 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.55 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4789086 | 0.87 | KCNH2 (0.54) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL4887320 | 0.85 | SCN9A (0.74) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL4788755 | 0.84 | SCN9A (0.75) | KCNH2SCN9ASCN5AGABRA5 | |
| SCHEMBL4789249 | 0.82 | KCNH2 (0.56) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL841196 | 0.81 | SCN5A (0.52) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL7030412 | 0.80 | MTNR1A (0.54) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL7030407 | 0.80 | MTNR1A (0.54) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL839810 | 0.80 | MTNR1A (0.44) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL7027930 | 0.80 | MTNR1A (0.65) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL7027929 | 0.80 | MTNR1A (0.65) | KCNH2SCN9ASCN5AMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130323-A1 | NOVEL 8-PIPERAZINE-TETRAHYDRONAPHTALENE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | claimed |
| WO-2008130323-A1 | NOVEL 8-PIPERAZINE-TETRAHYDRONAPHTALENE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |