Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.45 |
| ▸ | NCF1 | P14598 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4885849 | 0.84 | CSNK2A1 (0.44) | L3MBTL1KDM4ESMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL596640 | 0.84 | L3MBTL1 (0.37) | L3MBTL1KDM4EALDH1A1MAPTPOLB | |
| SCHEMBL4888139 | 0.83 | SMN1; SMN2 (0.42) | L3MBTL1SMN1; SMN2ALDH1A1MAPTCYP2C9 | |
| SCHEMBL4881875 | 0.83 | L3MBTL1 (0.40) | L3MBTL1KDM4ESMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL27639456 | 0.81 | MAPT (0.38) | L3MBTL1SMN1; SMN2ALDH1A1MAPTHPGD | |
| SCHEMBL2457659 | 0.81 | L3MBTL1 (0.43) | L3MBTL1NCF1KDM4EALDH1A1MAPT | |
| SCHEMBL2462595 | 0.80 | L3MBTL1 (0.41) | L3MBTL1NCF1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL2457214 | 0.80 | KDM4E (0.36) | L3MBTL1NCF1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL4885840 | 0.79 | HPGD (0.38) | L3MBTL1ALDH1A1MAPTPOLBHPGD | |
| SCHEMBL16973600 | 0.78 | L3MBTL1 (0.38) | L3MBTL1KDM4ESMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080293939-A1 | QUINAZOLINONE DERIVATIVES USEFUL AS ANTI-HYPERALGESIC AGENTS | CULSHAW ANDREW JAMES | 2008-11-27 | — | — | US | disclosed |
| CN-100432059-C | Quinazolinone derivatives useful as anti-hyperalgesic agents | NOVARTIS AG (CH) | 2008-11-12 | — | — | CN | disclosed |
| CN-1711249-A | Quinazolinone derivatives useful as anti-hyperalgesic agents | NOVARTIS AG (CH) | 2005-12-21 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293939-A1 | QUINAZOLINONE DERIVATIVES USEFUL AS ANTI-HYPERALGESIC AGENTS | OPRK1, OPRL1, TRPV1 | L3MBTL1 2929/4885NCF1 1429/4885KDM4E 3327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.