Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INPPL1 | O15357 | 8/20 | 0.72 |
| ▸ | LTA4H | P09960 | 1/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.51 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.51 |
| ▸ | DHFR | P00374 | 1/20 | 0.48 |
| ▸ | TEC | P42680 | 1/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 3/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.42 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL488102 | 0.80 | MAP4K4 (0.59) | INPPL1LTA4HMAP4K4CYP1A2KCNH2 | |
| SCHEMBL30454152 | 0.80 | MAP4K4 (0.59) | INPPL1LTA4HMAP4K4CYP1A2KCNH2 | |
| SCHEMBL11177596 | 0.78 | MAOB (0.59) | LTA4HCYP1A2DHFRTECMAOB | |
| SCHEMBL21076862 | 0.77 | INPPL1 (0.59) | INPPL1LTA4HMAP4K4KCNH2PIK3CD | |
| SCHEMBL22869172 | 0.75 | INPPL1 (0.56) | INPPL1LTA4HMAP4K4MINK1PIK3CD | |
| SCHEMBL16826233 | 0.75 | PIK3CD (0.61) | INPPL1LTA4HMAP4K4CYP1A2KCNH2 | |
| SCHEMBL9936469 | 0.74 | CYP11B1 (0.57) | INPPL1LTA4HMAP4K4CYP1A2PIK3CD | |
| SCHEMBL21044043 | 0.74 | INPPL1 (0.55) | INPPL1LTA4HMAP4K4CYP1A2KCNH2 | |
| SCHEMBL27650145 | 0.74 | FFAR1 (0.44) | INPPL1MAOB | |
| SCHEMBL312830 | 0.73 | LTA4H (0.79) | INPPL1LTA4HMAP4K4CYP1A2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106197-B2 | Aminoheteroaryl compounds as protein kinase inhibitors | PFIZER INC. (US) | 2012-01-31 | — | — | US | disclosed |
| US-20070072874-A1 | Aminoheteroaryl compounds as protein kinase inhibitors | SUGEN, INC. | 2007-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070072874-A1 | Aminoheteroaryl compounds as protein kinase inhibitors | MET, MAP4K1, MAP4K2 | INPPL1 1551/4885LTA4H 3789/4885MAP4K4 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.