Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Rosiglitazone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG known ✓ | P37231 | 15/20 | 0.92 |
| ▸ | RXRA | P19793 | 2/20 | 0.81 |
| ▸ | RARG | P13631 | 1/20 | 0.81 |
| ▸ | PPARA | Q07869 | 2/20 | 0.59 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rosiglitazone SCHEMBL4897990 | 0.99 | PPARG (0.91) | PPARGRXRARARGPPARAFFAR1 | |
| Rosiglitazone SCHEMBL29530259 | 0.96 | PPARG (1.00) | PPARGRXRARARGPPARAFFAR1 | |
| Rosiglitazone SCHEMBL11957687 | 0.96 | PPARG (1.00) | PPARGRXRARARGPPARAFFAR1 | |
| Rosiglitazone SCHEMBL5169 | 0.96 | PPARG (1.00) | PPARGRXRARARGPPARAFFAR1 | |
| Rosiglitazone SCHEMBL7052472 | 0.96 | PPARG (1.00) | PPARGRXRARARGPPARAFFAR1 | |
| Rosiglitazone SCHEMBL2355017 | 0.96 | PPARG (1.00) | PPARGRXRARARGPPARAFFAR1 | |
| Rosiglitazone SCHEMBL1489117 | 0.95 | PPARG (0.98) | PPARGRXRARARGPPARAFFAR1 | |
| Rosiglitazone SCHEMBL3377103 | 0.95 | PPARG (0.98) | PPARGRXRARARGPPARAFFAR1 | |
| Rosiglitazone SCHEMBL5468691 | 0.95 | PPARG (0.98) | PPARGRXRARARGPPARAFFAR1 | |
| Rosiglitazone SCHEMBL3375739 | 0.95 | PPARG (0.98) | PPARGRXRARARGPPARAFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080319024-A1 | Rosiglitazone Phosphate and Polymorphic Forms | GREIL JULIA | 2008-12-25 | — | — | US | claimed |
| EP-1735291-A2 | ROSIGLITAZONE PHOSPHATE AND POLYMORPHIC FORMS | Sandoz AG (CH) | 2006-12-27 | — | — | EP | claimed |
| WO-2005080358-A2 | ROSIGLITAZONE PHOSPHATE AND POLYMORPHIC FORMS | SANDOZ AG (CH) | 2005-09-01 | — | — | WO | claimed |
| US-20080319024-A1 | Rosiglitazone Phosphate and Polymorphic Forms | GREIL JULIA | 2008-12-25 | — | — | US | disclosed |
| US-20080319024-A1 | Rosiglitazone Phosphate and Polymorphic Forms | GREIL JULIA | 2008-12-25 | — | — | US | disclosed |
| CN-1964966-A | Rosiglitazone phosphate and polymorphic forms | SANDOZ AG (CH) | 2007-05-16 | — | — | CN | disclosed |
| CN-1964966-A | Rosiglitazone phosphate and polymorphic forms | SANDOZ AG (CH) | 2007-05-16 | — | — | CN | disclosed |
| CN-1964966-A | Rosiglitazone phosphate and polymorphic forms | SANDOZ AG (CH) | 2007-05-16 | — | — | CN | disclosed |
| WO-2005080358-A3 | ROSIGLITAZONE PHOSPHATE AND POLYMORPHIC FORMS | SANDOZ AG (CH) | 2006-12-28 | — | — | WO | disclosed |
| EP-1735291-A2 | ROSIGLITAZONE PHOSPHATE AND POLYMORPHIC FORMS | Sandoz AG (CH) | 2006-12-27 | — | — | EP | disclosed |
| EP-1735291-A2 | ROSIGLITAZONE PHOSPHATE AND POLYMORPHIC FORMS | Sandoz AG (CH) | 2006-12-27 | — | — | EP | disclosed |
| WO-2005080358-A2 | ROSIGLITAZONE PHOSPHATE AND POLYMORPHIC FORMS | SANDOZ AG (CH) | 2005-09-01 | — | — | WO | disclosed |
| WO-2005080358-A2 | ROSIGLITAZONE PHOSPHATE AND POLYMORPHIC FORMS | SANDOZ AG (CH) | 2005-09-01 | — | — | WO | disclosed |