Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK11 | Q15759 | 16/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 16/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6004439 | 0.88 | MAPK11 (0.49) | MAPK11MAPK14KCNH2ENPP2MAPK1 | |
| Isopropylamine SCHEMBL4890140 | 0.87 | MAPK11 (0.53) | MAPK11MAPK14KCNH2PTGER1 | |
| SCHEMBL3373577 | 0.81 | MAPK11 (0.59) | MAPK11MAPK14KCNH2PTGER1 | |
| SCHEMBL6004425 | 0.81 | MAPK11 (0.56) | MAPK11MAPK14KCNH2 | |
| SCHEMBL4761505 | 0.80 | MAPK11 (0.52) | MAPK11MAPK14KCNH2ENPP2 | |
| Isopropylamine SCHEMBL4924703 | 0.78 | MAPK11 (0.42) | MAPK11MAPK14KCNH2PTGER1 | |
| SCHEMBL4824475 | 0.78 | MAPK11 (0.51) | MAPK11MAPK14KCNH2 | |
| SCHEMBL4827940 | 0.76 | MAPK11 (0.61) | MAPK11MAPK14KCNH2MAPK1 | |
| SCHEMBL5256660 | 0.76 | MAPK11 (0.81) | MAPK11MAPK14KCNH2 | |
| SCHEMBL6003913 | 0.75 | MAPK11 (0.53) | MAPK11MAPK14KCNH2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871770-A1 | ORTHO-TERPHENYL INHIBITORS OF P38 KINASE AND METHODS OF TREATING INFLAMMATORY DISORDERS | Kalypsys, Inc. (US) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006116355-A1 | ORTHO-TERPHENYL INHIBITORS OF P38 KINASE AND METHODS OF TREATING INFLAMMATORY DISORDERS | KALYPSYS, INC. (US) | 2006-11-02 | — | — | WO | disclosed |