Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | LPL | P06858 | 1/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA3 | P07451 | 1/20 | 0.33 |
| ▸ | CA6 | P23280 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | P4HB | P07237 | 1/20 | 0.32 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL489376 | 0.79 | CCR1 (0.40) | ALDH1A1CA2LPLLIPG | |
| SCHEMBL30788696 | 0.79 | CCR1 (0.40) | ALDH1A1CA2LPLLIPG | |
| SCHEMBL6016 | 0.77 | ENPP2 (1.00) | ENPP2ALDH1A1CA2CYP2A6LPL | |
| SCHEMBL489235 | 0.74 | ENPP2 (0.58) | ENPP2ALDH1A1CA2CYP2A6LPL | |
| SCHEMBL15333016 | 0.72 | ENPP2 (0.86) | ENPP2ALDH1A1CA2CYP2A6LPL | |
| SCHEMBL29091391 | 0.72 | ENPP2 (0.86) | ENPP2ALDH1A1CA2CYP2A6LPL | |
| SCHEMBL9385634 | 0.71 | CYP11B2 (0.47) | ALDH1A1CYP2A6HSD11B1GAA | |
| SCHEMBL75729 | 0.67 | ENPP2 (0.76) | ENPP2ALDH1A1CA2LMNACA12 | |
| SCHEMBL2696908 | 0.67 | ENPP2 (0.76) | ENPP2ALDH1A1CA2CYP2A6LPL | |
| SCHEMBL2230653 | 0.67 | ENPP2 (0.76) | ENPP2ALDH1A1CA2LMNACA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106088-B2 | Fused bicyclic-substituted amines as histamine-3 receptor ligands | ABBOTT LABORATORIES (US) | 2012-01-31 | — | — | US | disclosed |
| EP-2311831-A1 | Fused bicyclic-substituted amines as histamine-3 receptor ligands | Abbott Laboratories (US) | 2011-04-20 | — | — | EP | disclosed |
| EP-1620434-B1 | FUSED BICYCLIC-SUBSTITUTED AMINES AS HISTAMINE-3 RECEPTOR LIGANDS | ABBOTT LAB (US) | 2011-03-09 | — | — | EP | disclosed |