Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.88 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.71 |
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.56 |
| ▸ | RECQL | P46063 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.56 |
| ▸ | BRAF | P15056 | 1/20 | 0.55 |
| ▸ | MAP3K5 | Q99683 | 6/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | EIF4E | P06730 | 1/20 | 0.55 |
| ▸ | EIF4G1 | Q04637 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | PTPN22 | Q9Y2R2 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4891702 | 1.00 | SYK (0.88) | SYKENPP2TNFRSF1AMEN1MAPT | |
| SCHEMBL1135868 | 0.94 | SYK (1.00) | SYKENPP2TNFRSF1AMEN1MAPT | |
| SCHEMBL30774050 | 0.94 | SYK (1.00) | SYKENPP2TNFRSF1AMEN1MAPT | |
| SCHEMBL1135867 | 0.94 | SYK (1.00) | SYKENPP2TNFRSF1AMEN1MAPT | |
| SCHEMBL12668370 | 0.94 | SYK (1.00) | SYKENPP2TNFRSF1AMEN1MAPT | |
| SCHEMBL4397326 | 0.84 | SYK (0.63) | SYKENPP2TNFRSF1AMEN1MAPT | |
| SCHEMBL4397324 | 0.84 | SYK (0.63) | SYKENPP2TNFRSF1AMEN1MAPT | |
| SCHEMBL4398637 | 0.84 | ENPP2 (1.00) | SYKENPP2MEN1MAPTKMT2A | |
| SCHEMBL4402019 | 0.84 | ENPP2 (1.00) | SYKENPP2MEN1MAPTKMT2A | |
| SCHEMBL23171552 | 0.80 | SYK (0.75) | SYKENPP2TNFRSF1AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080261980-A1 | Use of Thiazolidinone Derivatives as Antiangiogenic Agents | CELL THERAPEUTICS, INC. (US) | 2008-10-23 | — | — | US | disclosed |
| EP-1830848-A1 | USE OF THIAZOLIDINONE DERIVATIVES AS ANTIANGIOGENIC AGENTS | Cell Therapeutics Europe S.R.L. (IT) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066846-A1 | USE OF THIAZOLIDINONE DERIVATIVES AS ANTIANGIOGENIC AGENTS | CELL THERAPEUTICS EUROPE S.R.L. (IT) | 2006-06-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080261980-A1 | Use of Thiazolidinone Derivatives as Antiangiogenic Agents | EP300, HIF1A, HIF1AN | SYK 3137/4885ENPP2 2878/4885TNFRSF1A 2719/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.