Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 5/20 | 0.33 |
| ▸ | TEK | Q02763 | 5/20 | 0.33 |
| ▸ | EPHB4 | P54760 | 4/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | FLT1 | P17948 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4905656 | 0.82 | KDR (0.42) | ROCK2MAPK1KDRTEKEPHB4 | |
| SCHEMBL4871872 | 0.82 | ROCK2 (0.48) | ROCK2KDRTEKEPHB4EGFR | |
| SCHEMBL5223405 | 0.81 | ROCK2 (0.41) | MAPTKMT2ANPSR1KDM4EROCK2 | |
| SCHEMBL4877478 | 0.72 | ROCK2 (0.41) | MAPTKMT2ANPSR1KDM4ETDP1 | |
| SCHEMBL4874920 | 0.65 | KDR (0.58) | MAPTROCK2MAPK1KDRTEK | |
| SCHEMBL4866136 | 0.65 | KDR (0.58) | MAPTROCK2MAPK1KDRTEK | |
| SCHEMBL4870050 | 0.65 | KDR (0.58) | MAPTROCK2MAPK1KDRTEK | |
| SCHEMBL4870032 | 0.63 | TEK (0.69) | KMT2AROCK2KDRTEKEPHB4 | |
| SCHEMBL4002520 | 0.62 | ALDH1A1 (0.52) | ROCK2KDRTEKEPHB4EGFR | |
| SCHEMBL4002529 | 0.62 | ALDH1A1 (0.52) | ROCK2KDRTEKEPHB4EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080275029-A1 | Compounds for Treating Protein-Kinase Mediated Disorders | ASTEX THERAPEUTICS LIMITED (GB) | 2008-11-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080275029-A1 | Compounds for Treating Protein-Kinase Mediated Disorders | CNKSR1, PRKCH, PRKAR2B | MAPT 1204/4885KMT2A 1763/4885NPSR1 880/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.