Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.53 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.46 |
| ▸ | GCK | P35557 | 1/20 | 0.43 |
| ▸ | MECP2 | P51608 | 1/20 | 0.43 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.43 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.43 |
| ▸ | MBD2 | Q9UBB5 | 1/20 | 0.43 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.43 |
| ▸ | PPIA | P62937 | 6/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | FABP1 | P07148 | 1/20 | 0.40 |
| ▸ | FABP6 | P51161 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | ALPI | P09923 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4895056 | 0.85 | GRM5 (0.56) | GRM5SGMS2GCKPPIALTA4H | |
| SCHEMBL4892240 | 0.82 | KMT2A (0.49) | GRM5MECP2KCNN1KCNN2MBD2 | |
| SCHEMBL4901928 | 0.81 | MEN1 (0.48) | GRM5MECP2KCNN1KCNN2MBD2 | |
| SCHEMBL4901247 | 0.81 | GRM5 (0.48) | GRM5MECP2KCNN1KCNN2MBD2 | |
| Hydrochloric Acid SCHEMBL4900785 | 0.77 | GRM5 (0.50) | GRM5MECP2KCNN1KCNN2MBD2 | |
| SCHEMBL3142164 | 0.76 | GRM5 (0.58) | GRM5SGMS2GCKPPIALTA4H | |
| SCHEMBL14182367 | 0.74 | MECP2 (0.50) | GRM5MECP2KCNN1KCNN2MBD2 | |
| SCHEMBL4900015 | 0.74 | MECP2 (0.50) | GRM5MECP2KCNN1KCNN2MBD2 | |
| SCHEMBL4902684 | 0.71 | KDR (0.42) | GRM5LMNASMN1; SMN2L3MBTL1MEN1 | |
| SCHEMBL4892317 | 0.69 | MECP2 (0.43) | GRM5MECP2KCNN1KCNN2MBD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080108600-A1 | Polycyclic Pyridines as Potassium Ion Channel Modulators | ICAGEN, INC. (US) | 2008-05-08 | — | — | US | disclosed |
| US-20080108600-A1 | Polycyclic Pyridines as Potassium Ion Channel Modulators | ICAGEN, INC. (US) | 2008-05-08 | — | — | US | disclosed |
| US-20080108600-A1 | Polycyclic Pyridines as Potassium Ion Channel Modulators | ICAGEN, INC. (US) | 2008-05-08 | — | — | US | disclosed |
| EP-1737852-A2 | POLYCYCLIC PYRIDINES AS POTASSIUM ION CHANNEL MODULATORS | Icagen, Inc. (US) | 2007-01-03 | — | — | EP | disclosed |
| WO-2005100349-A2 | POLYCYCLIC PYRIDINES AS POTASSIUM ION CHANNEL MODULATORS | ICAGEN, INC. (US) | 2005-10-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080108600-A1 | Polycyclic Pyridines as Potassium Ion Channel Modulators | KCNJ2, KCNH2, KCNQ1 | GRM5 392/4885SGMS2 2126/4885GCK 1189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.