Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.56 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.49 |
| ▸ | GCK | P35557 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | PPIA | P62937 | 5/20 | 0.43 |
| ▸ | FABP1 | P07148 | 1/20 | 0.43 |
| ▸ | FABP6 | P51161 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4892374 | 0.85 | GRM5 (0.53) | GRM5SGMS2GCKLTA4HMAPK14 | |
| SCHEMBL4897041 | 0.83 | KMT2A (0.47) | GRM5SGMS2MEN1KMT2A | |
| SCHEMBL4899470 | 0.81 | GRM5 (0.50) | GRM5MEN1MAPK10GFERKMT2A | |
| SCHEMBL4904931 | 0.81 | GRM5 (0.50) | GRM5MEN1MAPK10GFERKMT2A | |
| SCHEMBL4902852 | 0.78 | GRM5 (0.53) | GRM5MEN1MAPK10GFERKMT2A | |
| SCHEMBL5259981 | 0.73 | KMT2A (0.47) | GRM5MEN1MAPK10GFERKMT2A | |
| SCHEMBL5259986 | 0.73 | KMT2A (0.48) | GRM5MEN1MAPK10GFERKMT2A | |
| SCHEMBL15577719 | 0.72 | L3MBTL1 (0.47) | LTA4HMAPK14 | |
| SCHEMBL5582996 | 0.72 | GRM5 (1.00) | GRM5GCK | |
| SCHEMBL2435879 | 0.71 | L3MBTL1 (0.44) | LTA4HMAPK14CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080108600-A1 | Polycyclic Pyridines as Potassium Ion Channel Modulators | ICAGEN, INC. (US) | 2008-05-08 | — | — | US | disclosed |
| CN-1980923-A | Polycyclic pyridines as potassium ion channel modulators | ICAGEN INC (US) | 2007-06-13 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080108600-A1 | Polycyclic Pyridines as Potassium Ion Channel Modulators | KCNJ2, KCNH2, KCNQ1 | GRM5 392/4885SGMS2 2126/4885GCK 1189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.