Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC1 | P19801 | 9/20 | 0.53 |
| ▸ | AOC3 | Q16853 | 9/20 | 0.53 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.47 |
| ▸ | CYP2E1 | P05181 | 3/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.47 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | MELK | Q14680 | 1/20 | 0.44 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL18986455 | 0.98 | AOC1 (0.55) | AOC1AOC3LOXL2CYP1A2CYP2E1 | |
| SCHEMBL4483018 | 0.84 | CYP1A2 (0.51) | AOC1AOC3LOXL2CYP1A2CYP2E1 | |
| SCHEMBL31119316 | 0.84 | CYP1A2 (0.51) | AOC1AOC3LOXL2CYP1A2CYP2E1 | |
| SCHEMBL12097845 | 0.82 | CYP1A2 (0.46) | AOC1AOC3LOXL2CYP1A2CYP2E1 | |
| SCHEMBL10175184 | 0.82 | CA12 (0.46) | CYP1A2CYP2E1CYP2A6CYP2B6CYP2C19 | |
| SCHEMBL17372010 | 0.81 | AOC3 (0.56) | AOC1AOC3LOXL2CYP1A2CYP2E1 | |
| SCHEMBL17372175 | 0.80 | AOC3 (0.46) | AOC1AOC3LOXL2CYP1A2CYP2E1 | |
| SCHEMBL29784977 | 0.80 | AOC3 (0.46) | AOC1AOC3LOXL2CYP1A2CYP2E1 | |
| SCHEMBL11483961 | 0.80 | HRH1 (0.44) | AOC1AOC3LOXL2CYP1A2CYP2E1 | |
| SCHEMBL7330298 | 0.80 | CA12 (0.41) | AOC1AOC3CYP1A2CYP2E1CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3723808-B1 | COMBINATION TREATMENTS COMPRISING ADMINISTRATION OF 1H-PYRAZOLO[4,3-B]PYRIDINES | H LUNDBECK AS (DK) | 2021-10-20 | — | — | EP | disclosed |
| EP-3723807-B1 | COMBINATION TREATMENTS COMPRISING ADMINISTRATION OF 1H-PYRAZOLO[4,3-B]PYRIDINES | H LUNDBECK AS (DK) | 2021-10-20 | — | — | EP | disclosed |
| US-11026923-B2 | 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors | H. LUNDBECK A/S (DK) | 2021-06-08 | — | — | US | disclosed |
| US-11026924-B2 | 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors | H. LUNDBECK A/S (DK) | 2021-06-08 | — | — | US | disclosed |
| US-20210023056-A1 | 1H-PYRAZOLO[4,3-B]PYRIDINES AS PDE1 INHIBITORS | H. LUNDBECK A/S (DK) | 2021-01-28 | — | — | US | disclosed |
| US-20210015794-A1 | 1H-PYRAZOLO[4,3-B]PYRIDINES AS PDE1 INHIBITORS | H. LUNDBECK A/S (DK) | 2021-01-21 | — | — | US | disclosed |
| US-20200385372-A1 | COMBINATION TREATMENTS COMPRISING ADMINISTRATION OF 1H-PYRAZOLO[4,3-B]PYRIDINES | H. LUNDBECK A/S (DK) | 2020-12-10 | — | — | US | disclosed |
| US-20200385381-A1 | COMBINATION TREATMENTS COMPRISING ADMINISTRATION OF 1H-PYRAZOLO[4,3-B]PYRIDINES | H. LUNDBECK A/S (DK) | 2020-12-10 | — | — | US | disclosed |
| US-20200375950-A1 | 1H-PYRAZOLO[4,3-B]PYRIDINES AS PDE1 INHIBITORS | H. LUNDBECK A/S (DK) | 2020-12-03 | — | — | US | disclosed |
| US-20200360343-A1 | 1H-PYRAZOLO[4,3-B]PYRIDINES AS PDE1 INHIBITORS | H. LUNDBECK A/S (DK) | 2020-11-19 | — | — | US | disclosed |
| EP-1860941-B1 | BIPHENYL-N-(4-PYRIDYL) METHYLSUFONAMIDES | BASF SE (DE) | 2008-11-12 | — | — | EP | disclosed |
| EP-1860941-B1 | BIPHENYL-N-(4-PYRIDYL) METHYLSUFONAMIDES | BASF SE (DE) | 2008-11-12 | — | — | EP | disclosed |
| US-20080161187-A1 | Controlling phytopathogenic harmful fungi and harmful arthropodes; combating arthropodal pestsprotecting crops, seeds and non-living materials from infestation by arthropodal pests; insecticides, pesticides, fungicides; miticides; agriculture; veterinary medicine | BASF AKTIENGESELLSCHAFT (DE) | 2008-07-03 | — | — | US | disclosed |
| US-20080161187-A1 | Controlling phytopathogenic harmful fungi and harmful arthropodes; combating arthropodal pestsprotecting crops, seeds and non-living materials from infestation by arthropodal pests; insecticides, pesticides, fungicides; miticides; agriculture; veterinary medicine | BASF AKTIENGESELLSCHAFT (DE) | 2008-07-03 | — | — | US | disclosed |
| US-20080161187-A1 | Controlling phytopathogenic harmful fungi and harmful arthropodes; combating arthropodal pestsprotecting crops, seeds and non-living materials from infestation by arthropodal pests; insecticides, pesticides, fungicides; miticides; agriculture; veterinary medicine | BASF AKTIENGESELLSCHAFT (DE) | 2008-07-03 | — | — | US | disclosed |
| CN-101141878-A | Biphenyl-n-(4-pyridyl)methylsulfonamides | BASF AG (DE) | 2008-03-12 | — | — | CN | disclosed |
| EP-1860941-A1 | BIPHENYL-N-(4-PYRIDYL) METHYLSUFONAMIDES | BASF AKTIENGESELLSCHAFT (DE) | 2007-12-05 | — | — | EP | disclosed |
| WO-2006097489-A1 | BIPHENYL-N-(4-PYRIDYL) METHYLSUFONAMIDES | BASF AKTIENGESELLSCHAFT (DE) | 2006-09-21 | — | — | WO | disclosed |
| US-4088766-A | PRODUCTION OF PROSTAGLANDINS IN MAMMALS | THE UPJOHN COMPANY (US) | 1978-05-09 | — | — | US | disclosed |
| US-4001256-A | PROSTAGLANDIN PRODUCTION IN MAMMALS | THE UPJOHN COMPANY (US) | 1977-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200375950-A1 | 1H-PYRAZOLO[4,3-B]PYRIDINES AS PDE1 INHIBITORS | PDE12, PDE3A, PDE5A | AOC1 605/4885AOC3 242/4885LOXL2 3267/4885 |
| US-11026924-B2 | 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors | PDE3A, PDE5A, PDE12 | AOC1 597/4885AOC3 243/4885LOXL2 3334/4885 |
| US-20080161187-A1 | Controlling phytopathogenic harmful fungi and harmful arthropodes; combating arthropodal pestsprotecting crops, seeds and non-living materials from infestation by arthropodal pests; insecticides, pesticides, fungicides; miticides; agriculture; veterinary medicine | PTPN21, PTPN1, PTPN14 | AOC1 1158/4885AOC3 959/4885LOXL2 1907/4885 |
| US-20200385372-A1 | COMBINATION TREATMENTS COMPRISING ADMINISTRATION OF 1H-PYRAZOLO[4,3-B]PYRIDINES | PDE3B, PDE1B, PDE12 | AOC1 289/4885AOC3 241/4885LOXL2 3910/4885 |
| US-20200385381-A1 | COMBINATION TREATMENTS COMPRISING ADMINISTRATION OF 1H-PYRAZOLO[4,3-B]PYRIDINES | PDE1B, PDE3B, PDE1A | AOC1 637/4885AOC3 387/4885LOXL2 3867/4885 |
| US-20200360343-A1 | 1H-PYRAZOLO[4,3-B]PYRIDINES AS PDE1 INHIBITORS | PDE3A, PDE5A, PDE12 | AOC1 597/4885AOC3 243/4885LOXL2 3334/4885 |
| US-11026923-B2 | 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors | PDE3A, PDE5A, PDE12 | AOC1 606/4885AOC3 238/4885LOXL2 3379/4885 |
| US-20210015794-A1 | 1H-PYRAZOLO[4,3-B]PYRIDINES AS PDE1 INHIBITORS | PDE3A, PDE5A, PDE12 | AOC1 597/4885AOC3 243/4885LOXL2 3334/4885 |
| US-20210023056-A1 | 1H-PYRAZOLO[4,3-B]PYRIDINES AS PDE1 INHIBITORS | PDE3A, PDE5A, PDE12 | AOC1 606/4885AOC3 238/4885LOXL2 3379/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.