SCHEMBL17372175

SCHEMBL17372175

COCCOc1cnccc1CN

nearest known ligand 0.46

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
AOC3 Q16853 9/20 0.46
AOC1 P19801 8/20 0.46
LOXL2 Q9Y4K0 1/20 0.44
BUB1 O43683 1/20 0.39
MELK Q14680 1/20 0.38
CCNT1 O60563 1/20 0.36
CDK9 P50750 1/20 0.36
CDK5 Q00535 1/20 0.36
CDK5R1 Q15078 1/20 0.36
LOX P28300 1/20 0.36
CYP1A2 P05177 2/20 0.36
CYP2E1 P05181 2/20 0.36
CYP2A6 P11509 2/20 0.36
CYP2B6 P20813 2/20 0.36
CYP2C19 P33261 2/20 0.36
CYP2C9 P11712 1/20 0.36
ATR Q13535 1/20 0.35
CYP2D6 P10635 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29784977 1.00 AOC3 (0.46) AOC3AOC1LOXL2BUB1MELK
SCHEMBL17372104 0.85 AOC3 (0.47) AOC3AOC1LOXL2BUB1CYP1A2
SCHEMBL26781479 0.83 AOC3 (0.46) AOC3AOC1LOXL2MELKLOX
SCHEMBL17372528 0.81 AOC3 (0.56) AOC3AOC1LOXL2BUB1LOX
SCHEMBL17372010 0.81 AOC3 (0.56) AOC3AOC1LOXL2MELKCYP1A2
SCHEMBL29784870 0.81 CHRNB2 (0.50) AOC3AOC1LOXL2
SCHEMBL17962481 0.81 CHRNB2 (0.50) AOC3AOC1LOXL2
SCHEMBL29784871 0.81 CHRNB2 (0.50) AOC3AOC1LOXL2
SCHEMBL17962490 0.81 AOC3 (0.43) AOC3AOC1LOXL2BUB1MELK
SCHEMBL4893069 0.80 AOC1 (0.53) AOC3AOC1LOXL2MELKCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3958865-B1 4H-PYRROLO[3,2-C]PYRIDIN-4-ONE DERIVATIVES BAYER AG (DE) 2025-12-10 EP disclosed
US-12403135-B2 4H-pyrrolo[3,2-c]pyridin-4-one derivatives BAYER AKTIENGESELLSCHAFT (DE) 2025-09-02 US disclosed
WO-2023173083-A1 TETRAHYDROINDOLE DERIVATIVES AS EGFR AND/OR HER2 INHIBTORS USEFUL FOR THE TREATMENT OF CANCER SCORPION THERAPEUTICS, INC. (US) 2023-09-14 WO disclosed
WO-2023173083-A1 TETRAHYDROINDOLE DERIVATIVES AS EGFR AND/OR HER2 INHIBTORS USEFUL FOR THE TREATMENT OF CANCER SCORPION THERAPEUTICS, INC. (US) 2023-09-14 WO disclosed
EP-3700904-B1 4H-PYRROLO[3,2-C]PYRIDIN-4-ONE DERIVATIVES BAYER AG (DE) 2023-07-19 EP disclosed
US-20220378762-A1 4H-PYRROLO[3,2-C]PYRIDIN-4-ONE DERIVATIVES BAYER AKTIENGESELLSCHAFT (DE) 2022-12-01 US disclosed
US-11339157-B1 4H-pyrrolo[3,2-c]pyridin-4-one derivatives BAYER AKTIENGESELLSCHAFT (DE) 2022-05-24 US disclosed
EP-3958865-A1 4H-PYRROLO[3,2-C]PYRIDIN-4-ONE DERIVATIVES Bayer Aktiengesellschaft (DE) 2022-03-02 EP disclosed
WO-2020216774-A1 4H-PYRROLO[3,2-C]PYRIDIN-4-ONE DERIVATIVES BAYER AKTIENGESELLSCHAFT (DE) 2020-10-29 WO disclosed
EP-3700904-A1 4H-PYRROLO[3,2-C]PYRIDIN-4-ONE DERIVATIVES Bayer AG (DE) 2020-09-02 EP disclosed
US-20180155285-A1 3-AMINO-1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONES BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2018-06-07 US disclosed
EP-3310775-A1 3-AMINO-1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONES BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2018-04-25 EP disclosed
US-20180016272-A1 4H-PYRROLO[3,2-C]PYRIDIN-4-ONE DERIVATIVES BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2018-01-18 US disclosed
EP-3250567-A1 4H-PYRROLO[3,2-C]PYRIDIN-4-ONE DERIVATIVES Bayer Pharma Aktiengesellschaft (DE) 2017-12-06 EP disclosed
WO-2017102649-A1 HETERO-1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONES BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2017-06-22 WO disclosed
EP-3157914-A1 3-AMINO-1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONES Bayer Pharma Aktiengesellschaft (DE) 2017-04-26 EP disclosed
US-20170101391-A1 3-AMINO-1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONES BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2017-04-13 US disclosed
WO-2016202755-A1 3-AMINO-1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONES BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2016-12-22 WO disclosed
WO-2016120196-A1 4H-PYRROLO[3,2-C]PYRIDIN-4-ONE DERIVATIVES BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2016-08-04 WO disclosed
WO-2015193339-A1 3-AMINO-1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONES BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2015-12-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170101391-A1 3-AMINO-1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONES BUB1, BUB1B, AURKB AOC3 4122/4885AOC1 4511/4885LOXL2 4391/4885
US-20220378762-A1 4H-PYRROLO[3,2-C]PYRIDIN-4-ONE DERIVATIVES EGFR, ERBB2, ERBB4 AOC3 3511/4885AOC1 2277/4885LOXL2 1254/4885
US-12403135-B2 4H-pyrrolo[3,2-c]pyridin-4-one derivatives EGFR, ERBB2, ERBB4 AOC3 3511/4885AOC1 2277/4885LOXL2 1254/4885
US-20180016272-A1 4H-PYRROLO[3,2-C]PYRIDIN-4-ONE DERIVATIVES CYP4B1, CYP3A4, CYP2C19 AOC3 1515/4885AOC1 2408/4885LOXL2 2224/4885
US-11339157-B1 4H-pyrrolo[3,2-c]pyridin-4-one derivatives CYP4B1, CYP2C19, CYP3A4 AOC3 1373/4885AOC1 2191/4885LOXL2 2608/4885
US-20180155285-A1 3-AMINO-1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONES HCCS, MCL1, MKI67 AOC3 3847/4885AOC1 4384/4885LOXL2 4101/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.