Chlorophenylpiperazine

Chlorophenylpiperazine

SCHEMBL48931

Clc1cccc(N2CCNCC2)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRB1 P08588 7/20 1.00
HTR3E A5X5Y0 4/20 1.00
HTR3B O95264 4/20 1.00
HTR3A P46098 4/20 1.00
HTR3D Q70Z44 4/20 1.00
HTR3C Q8WXA8 4/20 1.00
SIGMAR1 Q99720 3/20 1.00
HTR6 P50406 3/20 1.00
HTR1A P08908 2/20 1.00
HTR7 P34969 2/20 1.00
TP53 P04637 1/20 1.00
CYP1A2 P05177 1/20 1.00
CYP3A4 P08684 1/20 1.00
CYP2D6 P10635 1/20 1.00
THRB P10828 1/20 1.00
CYP2C9 P11712 1/20 1.00
HTR2A P28223 1/20 1.00
HTR2C P28335 1/20 1.00
SLC6A4 P31645 1/20 1.00
CYP2C19 P33261 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Chlorophenylpiperazine SCHEMBL8317392 1.00 ADRB1 (1.00) ADRB1HTR3EHTR3BHTR3AHTR3D
Chlorophenylpiperazine SCHEMBL29361195 1.00 ADRB1 (1.00) ADRB1HTR3EHTR3BHTR3AHTR3D
Chlorophenylpiperazine SCHEMBL20500310 0.98 ADRB1 (0.96) ADRB1HTR3EHTR3BHTR3AHTR3D
Chlorophenylpiperazine SCHEMBL27684638 0.98 ADRB1 (0.96) ADRB1HTR3EHTR3BHTR3AHTR3D
Chlorophenylpiperazine SCHEMBL1320253 0.98 ADRB1 (0.96) ADRB1HTR3EHTR3BHTR3AHTR3D
Chlorophenylpiperazine SCHEMBL264300 0.98 ADRB1 (0.96) ADRB1HTR3EHTR3BHTR3AHTR3D
Chlorophenylpiperazine SCHEMBL30914177 0.98 ADRB1 (0.96) ADRB1HTR3EHTR3BHTR3AHTR3D
Chlorophenylpiperazine SCHEMBL9070642 0.96 ADRB1 (0.93) ADRB1HTR3EHTR3BHTR3AHTR3D
Chlorophenylpiperazine SCHEMBL8523218 0.93 ADRB1 (0.87) ADRB1HTR3EHTR3BHTR3AHTR3D
SCHEMBL4925296 0.93 ADRB1 (0.87) ADRB1HTR3EHTR3BHTR3AHTR3D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2764 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12221438-B2 Continuous process for the preparation of trazodone AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) 2025-02-11 US claimed
CN-114965780-B Method for simultaneously measuring 30 mental active substances in environmental water body 中科检测技术服务(广州)股份有限公司 2024-09-24 CN claimed
US-20240252535-A1 CELLULAR COMPOSITION FOR TREATMENT OF DISEASES, DISORDERS OR CONDITIONS AND METHOD OF USE YZTHERAPEUTIC PERFORMANCE LTD. (IL) 2024-08-01 US claimed
US-20240245693-A1 COMPOSITIONS AND METHODS OF TISSUE REGENERATION THERAPY THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-07-25 US claimed
WO-2024150963-A1 NOVEL COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING SAME 광주과학기술원 2024-07-18 WO claimed
EP-4340940-A1 COMPOSITIONS AND METHODS OF TISSUE REGENERATION THERAPY The Regents of University of California (US) 2024-03-27 EP claimed
WO-2023218251-A1 NOVEL DEUTERIUM-ENRICHED NEFAZODONE ANALOGUES AND METHOD FOR PREPARING THEREOF CLEARSYNTH LABS LIMIED (IN) 2023-11-16 WO claimed
CN-116640418-B Electrochromic display device and preparation method thereof 苏州欧谱科显示科技有限公司 2023-11-03 CN claimed
CN-116640418-A Electrochromic material and preparation method and application thereof 苏州欧谱科显示科技有限公司 2023-08-25 CN claimed
EP-4208177-A1 CELLULAR COMPOSITION FOR TREATMENT OF DISEASES, DISORDERS OR CONDITIONS AND METHOD OF USE Yztherapeutic Performance Ltd. (IL) 2023-07-12 EP claimed
US-5788986-A Veterinary method for clinically modifying the behavior of dogs exhibiting canine affective aggression using R enantiomers, S enantiomers, and racemic mixtures of selective serotonin reuptake inhibitor compounds or their active metabolites TRUSTEES OF TUFTS COLLEGE (US) 1998-08-04 US claimed
US-5504086-A MAXIMIZING ANTIANXIETY, ANTICONVULSANT AND/OR HYPNOTIC EFFECTS; HUMAN CENTRAL NERVOUS SYSTEM; SIDE EFFECT REDUCTION ELLINWOOD JR EVERETT H (US) 1996-04-02 US claimed
EP-0635508-A1 TETRAHYDROPYRIDINE DERIVATIVE HAVING SUBSTITUENTS ON THREE RINGS Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1995-01-25 EP claimed
EP-0254623-B1 AMINOALKYLTHIO TRIAZOLOPYRIDINE OR TRIAZOLOQUINOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM, PARTICULARLY USEFUL AS ANTALGICS LABORATOIRES UPSA (FR) 1993-06-09 EP claimed
US-5209920-A Arthritis, administering a stimulant for the hypothalamic-pituitary adrenal axis and measuring hormone level THE UNITED STATES OF AMERICA AS REPRESENTED BY THE UNITED STATES DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1993-05-11 US claimed
EP-0539180-A1 Antiviral agents SANWA KAGAKU KENKYUSHO CO., LTD. (JP) 1993-04-28 EP claimed
EP-0494256-A4 EVALUATIVE MEANS FOR DETECTING INFLAMMATORY REACTIVITY AND FOR PREDICTING RESPONSE TO STRESS US HEALTH (US) 1992-08-12 EP claimed
EP-0494256-A1 EVALUATIVE MEANS FOR DETECTING INFLAMMATORY REACTIVITY AND FOR PREDICTING RESPONSE TO STRESS THE UNITED STATES OF AMERICA as represented by the Secretary UNITED STATES DEPARTMENT OF COMMERCE (US) 1992-07-15 EP claimed
WO-1991004479-A1 EVALUATIVE MEANS FOR DETECTING INFLAMMATORY REACTIVITY AND FOR PREDICTING RESPONSE TO STRESS THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, UNITED STATES DEPARTMENT OF COMMERCE (US) 1991-04-04 WO claimed
EP-0254623-A1 Aminoalkylthio triazolopyridine or triazoloquinoline derivatives, process for their preparation, medicaments containing them, particularly useful as antalgics LABORATOIRES UPSA (FR) 1988-01-27 EP claimed