Chlorophenylpiperazine

Chlorophenylpiperazine

SCHEMBL8317392

Clc1cccc(N2CCNCC2)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRB1 P08588 7/20 1.00
HTR3E A5X5Y0 4/20 1.00
HTR3B O95264 4/20 1.00
HTR3A P46098 4/20 1.00
HTR3D Q70Z44 4/20 1.00
HTR3C Q8WXA8 4/20 1.00
SIGMAR1 Q99720 3/20 1.00
HTR6 P50406 3/20 1.00
HTR1A P08908 2/20 1.00
HTR7 P34969 2/20 1.00
TP53 P04637 1/20 1.00
CYP1A2 P05177 1/20 1.00
CYP3A4 P08684 1/20 1.00
CYP2D6 P10635 1/20 1.00
THRB P10828 1/20 1.00
CYP2C9 P11712 1/20 1.00
HTR2A P28223 1/20 1.00
HTR2C P28335 1/20 1.00
SLC6A4 P31645 1/20 1.00
CYP2C19 P33261 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Chlorophenylpiperazine SCHEMBL48931 1.00 ADRB1 (1.00) ADRB1HTR3EHTR3BHTR3AHTR3D
Chlorophenylpiperazine SCHEMBL29361195 1.00 ADRB1 (1.00) ADRB1HTR3EHTR3BHTR3AHTR3D
Chlorophenylpiperazine SCHEMBL20500310 0.98 ADRB1 (0.96) ADRB1HTR3EHTR3BHTR3AHTR3D
Chlorophenylpiperazine SCHEMBL27684638 0.98 ADRB1 (0.96) ADRB1HTR3EHTR3BHTR3AHTR3D
Chlorophenylpiperazine SCHEMBL1320253 0.98 ADRB1 (0.96) ADRB1HTR3EHTR3BHTR3AHTR3D
Chlorophenylpiperazine SCHEMBL264300 0.98 ADRB1 (0.96) ADRB1HTR3EHTR3BHTR3AHTR3D
Chlorophenylpiperazine SCHEMBL30914177 0.98 ADRB1 (0.96) ADRB1HTR3EHTR3BHTR3AHTR3D
Chlorophenylpiperazine SCHEMBL9070642 0.96 ADRB1 (0.93) ADRB1HTR3EHTR3BHTR3AHTR3D
Chlorophenylpiperazine SCHEMBL8523218 0.93 ADRB1 (0.87) ADRB1HTR3EHTR3BHTR3AHTR3D
SCHEMBL4925296 0.93 ADRB1 (0.87) ADRB1HTR3EHTR3BHTR3AHTR3D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024150963-A1 NOVEL COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING SAME 광주과학기술원 2024-07-18 WO claimed
EP-0635508-B1 TETRAHYDROPYRIDINE DERIVATIVE HAVING SUBSTITUENTS ON THREE RINGS ASAHI CHEMICAL IND (JP) 1999-10-06 EP claimed
EP-0635508-A1 TETRAHYDROPYRIDINE DERIVATIVE HAVING SUBSTITUENTS ON THREE RINGS Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1995-01-25 EP claimed
WO-2024150963-A1 NOVEL COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING SAME 광주과학기술원 2024-07-18 WO disclosed
EP-0635508-B1 TETRAHYDROPYRIDINE DERIVATIVE HAVING SUBSTITUENTS ON THREE RINGS ASAHI CHEMICAL IND (JP) 1999-10-06 EP disclosed
US-5621103-A 3-(SUBSTITUTED METHYLAMINOCARBONYL)-1,2,3,4-TETRAHYDRO-(1)BENZOTHIENO(2,3-C) PYRIDINES; ANXIOLYTIC AGENTS; LEARNING ENHANCEMENT ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 1997-04-15 US disclosed
EP-0635508-A1 TETRAHYDROPYRIDINE DERIVATIVE HAVING SUBSTITUENTS ON THREE RINGS Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1995-01-25 EP disclosed