Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMKK2 | Q96RR4 | 4/20 | 0.62 |
| ▸ | LCK | P06239 | 4/20 | 0.52 |
| ▸ | IKBKB | O14920 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.49 |
| ▸ | ABL1 | P00519 | 10/20 | 0.49 |
| ▸ | BCR | P11274 | 5/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 8/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.48 |
| ▸ | KIT | P10721 | 5/20 | 0.48 |
| ▸ | LYN | P07948 | 3/20 | 0.48 |
| ▸ | FLT3 | P36888 | 3/20 | 0.48 |
| ▸ | DDR2 | Q16832 | 3/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | PRKCA | P17252 | 1/20 | 0.47 |
| ▸ | LDLR | P01130 | 1/20 | 0.46 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4893357 | 0.85 | ABL1 (0.61) | CAMKK2LCKIKBKBABL1BCR | |
| SCHEMBL4899264 | 0.85 | JAK2 (0.66) | CAMKK2IKBKBJAK2MAPK8ABL1 | |
| SCHEMBL4901347 | 0.85 | PDGFRA (0.69) | LCKMAPK8ABL1BCRPDGFRA | |
| SCHEMBL4904288 | 0.84 | CAMKK2 (0.71) | CAMKK2LCKMAPK8ABL1BCR | |
| SCHEMBL4900996 | 0.83 | PDGFRA (0.70) | LCKMAPK8ABL1BCRPDGFRA | |
| SCHEMBL4902199 | 0.83 | ABL1 (0.63) | CAMKK2IKBKBJAK2MAPK8ABL1 | |
| SCHEMBL4899621 | 0.81 | PDGFRA (0.57) | LCKABL1BCRPDGFRAPDGFRB | |
| SCHEMBL4902240 | 0.81 | ABL1 (0.71) | LCKMAPK8ABL1BCRPDGFRA | |
| SCHEMBL4903439 | 0.81 | IKBKB (0.50) | CAMKK2IKBKBABL1BCRPDGFRA | |
| SCHEMBL4891653 | 0.81 | PDGFRA (0.70) | LCKABL1BCRPDGFRAPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080187575-A1 | Pyrimidine Derivatives | VICHEM CHEMIE KFT (HU) | 2008-08-07 | — | — | US | claimed |
| EP-1786781-A2 | PYRIMIDINE DERIVATIVES | GPC Biotech AG (DE) | 2007-05-23 | — | — | EP | claimed |
| WO-2006021458-A2 | PYRIMIDINE DERIVATIVES | GPC BIOTECH AG (DE) | 2006-03-02 | — | — | WO | claimed |
| US-20080187575-A1 | Pyrimidine Derivatives | VICHEM CHEMIE KFT (HU) | 2008-08-07 | — | — | US | disclosed |
| EP-1786781-A2 | PYRIMIDINE DERIVATIVES | GPC Biotech AG (DE) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006021458-A2 | PYRIMIDINE DERIVATIVES | GPC BIOTECH AG (DE) | 2006-03-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080187575-A1 | Pyrimidine Derivatives | TYMP, TDP1, PNP | CAMKK2 4550/4885LCK 328/4885IKBKB 875/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.