SCHEMBL489391

SCHEMBL489391

CCCCCCCCCC=CC=CC=Cc1ccccc1C=O

nearest known ligand 0.50

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.50
TSHR P16473 1/20 0.50
FASN P49327 1/20 0.41
FAAH O00519 8/20 0.41
CYSLTR2 Q9NS75 2/20 0.41
CYSLTR1 Q9Y271 2/20 0.41
TRPV1 Q8NER1 2/20 0.41
SOAT2 O75908 1/20 0.40
SOAT1 P35610 1/20 0.40
MEN1 O00255 1/20 0.39
LMNA P02545 1/20 0.39
THRB P10828 1/20 0.39
BLM P54132 1/20 0.39
KMT2A Q03164 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
EPHX2 P34913 2/20 0.38
CNR1 P21554 1/20 0.36
CNR2 P34972 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3523568 0.98 TSHR (0.47) ALDH1A1TSHRFASNFAAHCYSLTR2
SCHEMBL10482226 0.87 CYSLTR2 (0.50) ALDH1A1TSHRFAAHCYSLTR2CYSLTR1
SCHEMBL3525106 0.87 CYSLTR2 (0.50) ALDH1A1TSHRFAAHCYSLTR2CYSLTR1
SCHEMBL9857570 0.87 CYSLTR2 (0.50) ALDH1A1TSHRFAAHCYSLTR2CYSLTR1
SCHEMBL8500643 0.87 CYSLTR2 (0.50) ALDH1A1TSHRFAAHCYSLTR2CYSLTR1
SCHEMBL8500639 0.87 CYSLTR2 (0.50) ALDH1A1TSHRFAAHCYSLTR2CYSLTR1
SCHEMBL8817912 0.83 ALDH1A1 (0.43) ALDH1A1TSHRFASNFAAHCYSLTR2
SCHEMBL8817905 0.83 ALDH1A1 (0.43) ALDH1A1TSHRFASNFAAHCYSLTR2
SCHEMBL4451953 0.82 CDK4 (0.45) ALDH1A1TSHRFASNFAAHCYSLTR2
SCHEMBL19858999 0.82 CDK4 (0.45) ALDH1A1TSHRFASNFAAHCYSLTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1515723-B1 SUBSTITUTED DIHYDROPYRIMIDONES AND DIHYDROPYRIMIDINETHIONES AS CALCIUM CHANNEL BLOCKERS VITTAL MALLYA SCIENT RES FOUNDATION (IN) 2014-02-12 EP disclosed
US-8106062-B1 Calcium channel blockers DIAKRON PHARMACEUTICALS, INC. (US) 2012-01-31 US disclosed
EP-1542683-A2 CALCIUM CHANNEL BLOCKERS Diakron Pharmaceuticals, Inc. (US) 2005-06-22 EP disclosed
EP-1515723-A2 SUBSTITUTED DIHYDROPYRIMIDONES AND DIHYDROPYRIMIDINETHIONES AS CALCIUM CHANNEL BLOCKERS VITTAL MALLYA SCIENTIFIC RESEARCH FOUNDATION (IN) 2005-03-23 EP disclosed
WO-2004024153-A2 CALCIUM CHANNEL BLOCKERS DIAKRON PHARMACEUTICALS, INC. (US) 2004-03-25 WO disclosed
WO-2003105854-A2 SUBSTITUTED DIHYDROPYRIMIDINES, DIHYDROPYRIMIDONES AND DIHYDROPYRIMIDINETHIONES AS CALCIUM CHANNEL BLOCKERS VITTAL MALLYA SCIENTIFIC RESEARCH FOUNDATION (IN) 2003-12-24 WO disclosed