SCHEMBL8500643

SCHEMBL8500643

CCCCCCC=Cc1ccccc1C=O

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYSLTR2 Q9NS75 2/20 0.50
CYSLTR1 Q9Y271 2/20 0.50
FAAH O00519 4/20 0.46
TRPV1 Q8NER1 2/20 0.46
MEN1 O00255 1/20 0.45
LMNA P02545 1/20 0.45
THRB P10828 1/20 0.45
BLM P54132 1/20 0.45
KMT2A Q03164 1/20 0.45
TDP1 Q9NUW8 1/20 0.45
SOAT2 O75908 1/20 0.43
SOAT1 P35610 1/20 0.43
EPHX2 P34913 2/20 0.41
PDE5A O76074 1/20 0.41
TSHR P16473 3/20 0.41
CNR1 P21554 1/20 0.40
CNR2 P34972 1/20 0.40
MGLL Q99685 1/20 0.39
ALDH1A1 P00352 2/20 0.39
OXER1 Q8TDS5 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8500639 1.00 CYSLTR2 (0.50) CYSLTR2CYSLTR1FAAHTRPV1MEN1
SCHEMBL3525106 1.00 CYSLTR2 (0.50) CYSLTR2CYSLTR1FAAHTRPV1MEN1
SCHEMBL9857570 1.00 CYSLTR2 (0.50) CYSLTR2CYSLTR1FAAHTRPV1MEN1
SCHEMBL10482226 1.00 CYSLTR2 (0.50) CYSLTR2CYSLTR1FAAHTRPV1MEN1
SCHEMBL6046925 0.89 CYSLTR2 (0.50) CYSLTR2CYSLTR1FAAHTRPV1SOAT2
SCHEMBL3523568 0.89 TSHR (0.47) CYSLTR2CYSLTR1FAAHTRPV1MEN1
SCHEMBL489391 0.87 ALDH1A1 (0.50) CYSLTR2CYSLTR1FAAHTRPV1MEN1
SCHEMBL13278006 0.85 CYSLTR2 (0.44) CYSLTR2CYSLTR1FAAHTRPV1SOAT2
SCHEMBL13278008 0.85 CYSLTR2 (0.44) CYSLTR2CYSLTR1FAAHTRPV1SOAT2
SCHEMBL11835702 0.83 CYSLTR2 (0.53) CYSLTR2CYSLTR1FAAHTRPV1SOAT2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5952316-A FOR TREATING AUTOIMMUNE DISEASES, E.G., RHEUMATIOD ARTHRITIS YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1999-09-14 US disclosed
EP-0627406-B1 2-AMINO-1,3-PROPANEDIOL COMPOUND AND IMMUNOSUPPRESSANT YOSHITOMI PHARMACEUTICAL (JP) 1998-10-28 EP disclosed
US-5719176-A 2-amino-1,3-propanediol compound and immunosuppressant YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1998-02-17 US disclosed
US-5604229-A 2-amino-1,3-propanediol compound and immunosuppressant YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1997-02-18 US disclosed
EP-0627406-A1 2-AMINO-1,3-PROPANEDIOL COMPOUND AND IMMUNOSUPPRESSANT YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1994-12-07 EP disclosed