Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 1/20 | 0.61 |
| ▸ | THRB | P10828 | 1/20 | 0.61 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.47 |
| ▸ | PTGER3 | P43115 | 4/20 | 0.47 |
| ▸ | PTGER2 | P43116 | 4/20 | 0.47 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4895271 | 1.00 | THRA (0.61) | THRATHRBRECQLMAPTPTGER4 | |
| SCHEMBL4897742 | 0.78 | ALDH1A1 (0.47) | THRATHRBMAPTGAAALDH1A1 | |
| SCHEMBL4897739 | 0.78 | ALDH1A1 (0.47) | THRATHRBMAPTGAAALDH1A1 | |
| SCHEMBL4900593 | 0.77 | KDM4E (0.50) | THRATHRBPTGER4PTGER3PTGER2 | |
| SCHEMBL4900599 | 0.77 | KDM4E (0.50) | THRATHRBPTGER4PTGER3PTGER2 | |
| SCHEMBL4897125 | 0.76 | THRA (0.62) | THRATHRBRECQLALDH1A1LMNA | |
| SCHEMBL4897130 | 0.76 | THRA (0.62) | THRATHRBRECQLALDH1A1LMNA | |
| SCHEMBL4892311 | 0.76 | THRA (1.00) | THRATHRBPTGER4PTGER3PTGER2 | |
| SCHEMBL29407130 | 0.76 | RECQL (0.75) | RECQLMAPTPTGER4PTGER3PTGER2 | |
| SCHEMBL4900945 | 0.76 | KDM4E (0.42) | PTGER1GAAALDH1A1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080027096-A1 | Novel Pharmaceutical Compositions | KARO BIO AB (SE) | 2008-01-31 | — | — | US | disclosed |
| EP-1729756-A2 | NOVEL PHARMACEUTICAL COMPOSITIONS | KARO BIO AB (SE) | 2006-12-13 | — | — | EP | disclosed |
| WO-2005094810-A2 | NOVEL PHARMACEUTICAL COMPOSITIONS | KARO BIO AB (SE) | 2005-10-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080027096-A1 | Novel Pharmaceutical Compositions | AR, NR5A1, CYP17A1 | THRA 559/4885THRB 792/4885RECQL 4370/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.