Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14066526 | 0.84 | HDAC1 (0.71) | ALDH1A1SMN1; SMN2MAPTHDAC1HDAC3 | |
| SCHEMBL4260699 | 0.82 | HDAC1 (0.50) | POLBALDH1A1SMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL4260702 | 0.82 | HDAC1 (0.50) | POLBALDH1A1SMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL4895567 | 0.81 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2CYP1A2CYP3A4MAPT | |
| SCHEMBL2733603 | 0.81 | KDM4E (0.62) | ALDH1A1SMN1; SMN2CYP3A4CYP2C9L3MBTL1 | |
| SCHEMBL4897570 | 0.80 | HDAC1 (0.66) | ALDH1A1SMN1; SMN2MAPTHDAC1HDAC3 | |
| SCHEMBL4896072 | 0.79 | HDAC1 (0.68) | ALDH1A1SMN1; SMN2MAPTHDAC1HDAC3 | |
| SCHEMBL14066528 | 0.78 | HDAC1 (0.66) | ALDH1A1SMN1; SMN2MAPTHDAC1HDAC3 | |
| SCHEMBL4896610 | 0.78 | ADRA1D (0.59) | ALDH1A1CYP1A2MAPTCYP2C9CYP2C19 | |
| SCHEMBL4898854 | 0.78 | HDAC1 (0.57) | ALDH1A1SMN1; SMN2CYP3A4MAPTCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080234254-A1 | Inhibitors of Histone Deacetylase | UNIVERSITY OF LEEDS (GB) | 2008-09-25 | — | — | US | disclosed |
| US-20080234254-A1 | Inhibitors of Histone Deacetylase | UNIVERSITY OF LEEDS (GB) | 2008-09-25 | — | — | US | disclosed |
| US-20080234254-A1 | Inhibitors of Histone Deacetylase | UNIVERSITY OF LEEDS (GB) | 2008-09-25 | — | — | US | disclosed |
| WO-2005121073-A1 | INHIBITORS OF HISTONE DEACETYLASE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2005-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234254-A1 | Inhibitors of Histone Deacetylase | HDAC8, HDAC4, HDAC5 | POLB 1108/4885ALDH1A1 1078/4885SMN1; SMN2 4631/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.