Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Clenbuterol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 4/20 | 0.79 |
| ▸ | LMNA | P02545 | 5/20 | 0.79 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.79 |
| ▸ | TSHR | P16473 | 2/20 | 0.79 |
| ▸ | HTR1A | P08908 | 1/20 | 0.79 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.79 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.79 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.79 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.79 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.79 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.77 |
| ▸ | CASP7 | P55210 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Clenbuterol SCHEMBL10614465 | 0.91 | LMNA (0.86) | LMNAADRB1ADRB2TSHRHTR1A | |
| Clenbuterol SCHEMBL20761507 | 0.89 | ADRB1 (1.00) | LMNAADRB1ADRB2TSHRHTR1A | |
| Clenbuterol SCHEMBL4723 | 0.89 | ADRB1 (1.00) | LMNAADRB1ADRB2TSHRHTR1A | |
| Clenbuterol SCHEMBL4722 | 0.89 | ADRB1 (1.00) | LMNAADRB1ADRB2TSHRHTR1A | |
| Clenbuterol SCHEMBL123545 | 0.87 | LMNA (1.00) | LMNAADRB1ADRB2TSHRHTR1A | |
| Clenbuterol SCHEMBL28145163 | 0.87 | LMNA (1.00) | LMNAADRB1ADRB2TSHRHTR1A | |
| Clenbuterol SCHEMBL27992618 | 0.86 | ADRB1 (0.94) | LMNAADRB1ADRB2TSHRHTR1A | |
| SCHEMBL10614322 | 0.84 | LMNA (0.74) | LMNAADRB1ADRB2TSHRHTR1A | |
| SCHEMBL23570867 | 0.81 | ADRB1 (0.78) | LMNAADRB1ADRB2TSHRHTR1A | |
| SCHEMBL30083793 | 0.80 | ADRB1 (0.81) | LMNAADRB1ADRB2TSHRHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080287467-A1 | Therapeutic Agent for Respiratory Diseases | ONO PHARMACEUTICAL CO., LTD. (JP) | 2008-11-20 | — | — | US | disclosed |