Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.78 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.78 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.78 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.78 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.78 |
| ▸ | CACNA1C | Q13936 | 4/20 | 0.78 |
| ▸ | TSHR | P16473 | 3/20 | 0.78 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.78 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.78 |
| ▸ | MEN1 | O00255 | 1/20 | 0.78 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.47 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.47 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.47 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.44 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.44 |
| ▸ | GMNN | O75496 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28830138 | 1.00 | MAPT (0.78) | MAPTCYP1A2CYP3A4ADORA3CYP2C9 | |
| SCHEMBL10408513 | 1.00 | MAPT (0.78) | MAPTCYP1A2CYP3A4ADORA3CYP2C9 | |
| SCHEMBL29394850 | 0.91 | MAPT (0.78) | MAPTCYP1A2CYP3A4ADORA3CYP2C9 | |
| SCHEMBL2845539 | 0.87 | CYP1A2 (1.00) | MAPTCYP1A2CYP3A4ADORA3CYP2C9 | |
| SCHEMBL718828 | 0.87 | CYP1A2 (1.00) | MAPTCYP1A2CYP3A4ADORA3CYP2C9 | |
| SCHEMBL133106 | 0.87 | CYP1A2 (1.00) | MAPTCYP1A2CYP3A4ADORA3CYP2C9 | |
| SCHEMBL29359402 | 0.87 | CYP1A2 (1.00) | MAPTCYP1A2CYP3A4ADORA3CYP2C9 | |
| SCHEMBL30897545 | 0.87 | CYP1A2 (1.00) | MAPTCYP1A2CYP3A4ADORA3CYP2C9 | |
| SCHEMBL9672747 | 0.86 | CACNA1C (0.58) | MAPTCYP1A2CYP3A4ADORA3CYP2C9 | |
| SCHEMBL7265346 | 0.85 | CYP1A2 (0.80) | MAPTCYP1A2CYP3A4ADORA3CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9458131-B2 | Compounds and compositions used to epigenetically transform cells and methods related thereto | EMORY UNIVERSITY (US) | 2016-10-04 | — | — | US | claimed |
| US-20150259649-A1 | CELLULAR COMPOSITIONS USED TO RESTORE STEM CELL OR PROGENITOR CELL FUNCTION AND METHODS RELATED THERETO | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-09-17 | — | — | US | claimed |
| US-20140294764-A1 | COMPOUNDS AND COMPOSITIONS USED TO EPIGENETICALLY TRANSFORM CELLS AND METHODS RELATED THERETO | ISTITUTO PASTEUR - FONDAZIONE CENCI BOLOGNETTI (IT) | 2014-10-02 | — | — | US | claimed |
| US-20220168300-A1 | Methods of Managing Vascular Conditions and Diabetic Peripheral Neuropathies | UNIV EMORY (US) | 2022-06-02 | — | — | US | disclosed |
| US-10828331-B2 | Cellular compositions used to restore stem cell or progenitor cell function and methods related thereto | EMORY UNIVERSITY (US) | 2020-11-10 | — | — | US | disclosed |
| US-20170157178-A1 | Cellular Compositions Used To Restore Stem Cell or Progenitor Cell Function and Methods Related Thereto | UNIV EMORY (US) | 2017-06-08 | — | — | US | disclosed |
| US-9458131-B2 | Compounds and compositions used to epigenetically transform cells and methods related thereto | EMORY UNIVERSITY (US) | 2016-10-04 | — | — | US | disclosed |
| US-20150296779-A1 | SUBSTITUTED DIHYDROPYRIDINES FOR SOMATIC EMBRYOGENESIS IN PLANTS | STICHTING DIENST LANDBOUWKUNDIG ONDERZOEK (NL) | 2015-10-22 | — | — | US | disclosed |
| US-20150259649-A1 | CELLULAR COMPOSITIONS USED TO RESTORE STEM CELL OR PROGENITOR CELL FUNCTION AND METHODS RELATED THERETO | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-09-17 | — | — | US | disclosed |
| US-20140294764-A1 | COMPOUNDS AND COMPOSITIONS USED TO EPIGENETICALLY TRANSFORM CELLS AND METHODS RELATED THERETO | ISTITUTO PASTEUR - FONDAZIONE CENCI BOLOGNETTI (IT) | 2014-10-02 | — | — | US | disclosed |
| US-8709804-B2 | Method for drug screening and characterization by calcium flux | CEDARS-SINAI MEDICAL CENTER (US) | 2014-04-29 | — | — | US | disclosed |
| US-4804665-A | NERVOUS SYSTEM DISORDERS; COGNITION ACTIVATORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1989-02-14 | — | — | US | disclosed |
| US-4764516-A | Mixtures of optically active nitrodihydropyridines active on the circulatory system | BAYER AKTIENGESELLSCHAFT (DE) | 1988-08-16 | — | — | US | disclosed |
| EP-0273659-A1 | Azaspiro compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1988-07-06 | — | — | EP | disclosed |
| EP-0273349-A2 | Resolution of 1,4-dihydropyridine derivatives | LABORATOIRES SYNTEX S.A. (FR) | 1988-07-06 | — | — | EP | disclosed |
| EP-0218089-B1 | OPTICALLY ACTIVE (METH)-ACRYL AMIDE, POLYMERS THEREOF, PROCESS FOR THEIR PREPARATION AND THEIR USE IN THE SEPARATION OF RACEMATES | BAYER AG (DE) | 1988-06-22 | — | — | EP | disclosed |
| EP-0071819-B1 | DIHYDROPYRIDINES WITH A POSITIVE INOTROPIC ACTIVITY, THEIR USE IN PHARMACEUTICAL PREPARATIONS, AND PROCESSES FOR THEIR PREPARATION | BAYER AG (DE) | 1987-04-22 | — | — | EP | disclosed |
| EP-0186028-A2 | Optically active nitrodihydropyridines, process for their preparation and their use in medicines | BAYER AG (DE) | 1986-07-02 | — | — | EP | disclosed |
| US-4532248-A | Administering 1,4-dihydropyridine derivative exhibiting positive inotropic activity | BAYER AKTIENGESELLSCHAFT (DE) | 1985-07-30 | — | — | US | disclosed |
| EP-0071819-A1 | Dihydropyridines with a positive inotropic activity, their use in pharmaceutical preparations, and processes for their preparation | BAYER AG (DE) | 1983-02-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10828331-B2 | Cellular compositions used to restore stem cell or progenitor cell function and methods related thereto | BMI1, DNMT1, DNMT3A | MAPT 3430/4885CYP1A2 4858/4885CYP3A4 4880/4885 |
| US-20170157178-A1 | Cellular Compositions Used To Restore Stem Cell or Progenitor Cell Function and Methods Related Thereto | BMI1, DNMT1, DNMT3A | MAPT 3430/4885CYP1A2 4858/4885CYP3A4 4880/4885 |
| US-20140294764-A1 | COMPOUNDS AND COMPOSITIONS USED TO EPIGENETICALLY TRANSFORM CELLS AND METHODS RELATED THERETO | BMI1, DNMT3L, DNMT3B | MAPT 2598/4885CYP1A2 2795/4885CYP3A4 3022/4885 |
| US-20150259649-A1 | CELLULAR COMPOSITIONS USED TO RESTORE STEM CELL OR PROGENITOR CELL FUNCTION AND METHODS RELATED THERETO | BMI1, DNMT1, DNMT3A | MAPT 3430/4885CYP1A2 4858/4885CYP3A4 4880/4885 |
| US-20150296779-A1 | SUBSTITUTED DIHYDROPYRIDINES FOR SOMATIC EMBRYOGENESIS IN PLANTS | SALL4, KCNK4, CDKL4 | MAPT 3825/4885CYP1A2 932/4885CYP3A4 324/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.